School of Chemistry and Chemical Engineering, Dezhou University, Dezhou 253023, China.
School of Life Sciences, Dezhou University, Dezhou 253023, China.
Molecules. 2022 Nov 30;27(23):8348. doi: 10.3390/molecules27238348.
The overuse of antibiotics has led to severe bacterial drug resistance. Blocking pathogen virulence devices is a highly effective approach to combating bacterial resistance worldwide. Type three secretion systems (T3SSs) are significant virulence factors in Gram-negative pathogens. Inhibition of these systems can effectively weaken infection whilst having no significant effect on bacterial growth. Therefore, T3SS inhibitors may be a powerful weapon against resistance in Gram-negative bacteria, and there has been increasing interest in the research and development of T3SS inhibitors. This review outlines several reported small-molecule inhibitors of the T3SS, covering those of synthetic and natural origin, including their sources, structures, and mechanisms of action.
抗生素的过度使用导致了严重的细菌耐药性。阻断病原体毒力装置是全球对抗细菌耐药性的一种非常有效的方法。III 型分泌系统（T3SS）是革兰氏阴性病原体的重要毒力因子。抑制这些系统可以有效地削弱感染，而对细菌生长没有显著影响。因此，T3SS 抑制剂可能是对抗革兰氏阴性菌耐药性的有力武器，人们对 T3SS 抑制剂的研究和开发越来越感兴趣。本文综述了几种已报道的 T3SS 的小分子抑制剂，包括合成和天然来源的抑制剂，涵盖了它们的来源、结构和作用机制。
