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基于多糖载体的亲水性基质缓释系统。

Hydrophilic matrix sustained release systems based on polysaccharide carriers.

作者信息

Melia C D

机构信息

Department of Pharmaceutical Sciences, University of Nottingham, U.K.

出版信息

Crit Rev Ther Drug Carrier Syst. 1991;8(4):395-421.

PMID:1769067
Abstract

The hydrophilic matrix (HM) continues to be a popular and widely used strategy for sustained-release drug delivery, with polysaccharides and their derivatives being the polymers of choice as the rate-controlling carriers for these systems. This review provides an appraisal of the more recent developments in the design and in our understanding of the behavior of HM systems. It also focuses on areas of current interest not encompassed by previous reviews.

摘要

亲水性基质（HM）仍然是一种常用且广泛应用于缓释药物递送的策略，多糖及其衍生物作为这些系统的控释载体聚合物是首选。本综述对HM系统的设计及其行为理解方面的最新进展进行了评估。它还聚焦于先前综述未涵盖的当前感兴趣的领域。

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