Jessop Sue
Division of Dermatology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Dermatol Clin. 2006 Oct;24(4):509-20, vii. doi: 10.1016/j.det.2006.06.006.
Kaposi's sarcoma (KS) is a multifocal vascular tumor that occurs most commonly in patients who have immunosuppression caused by HIV. KS-associated herpes virus (human herpes virus 8, KSHV) has been identified as the causative agent. There are marked geographic differences in the prevalence of both KS and seropositivity to KSHV. The incidence of the tumor has shown a marked decline in first-world countries with the widespread use of effective antiretroviral therapy. The most effective anthracycline is pegylated liposomal doxorubicin; however, few developing countries, where KS prevalence is highest, can afford to use these agents.
卡波西肉瘤（KS）是一种多灶性血管肿瘤，最常见于因人类免疫缺陷病毒（HIV）导致免疫抑制的患者。卡波西肉瘤相关疱疹病毒（人类疱疹病毒8型，KSHV）已被确定为病原体。KS的患病率和KSHV血清阳性率在地理上存在显著差异。随着有效抗逆转录病毒疗法的广泛应用，这种肿瘤在发达国家的发病率已显著下降。最有效的蒽环类药物是聚乙二醇化脂质体阿霉素；然而，在KS患病率最高的少数发展中国家，无力承担使用这些药物的费用。
