Naranjo Victoria, Gortazar Christian, Villar Margarita, de la Fuente José
Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ronda de Toledo s/n, 13071 Ciudad Real, Spain.
Anim Health Res Rev. 2007 Jun;8(1):81-8. doi: 10.1017/S1466252307001260.
Bovine tuberculosis (bTB) is an established zoonotic disease which affects cattle and wildlife worldwide and new strategies are required to control and eradicate the disease. The European wild boar (Sus scrofa) is a major reservoir of bTB in Spain. The objective of this paper was to review tissue-specific response and function of mandibular lymph nodes (MLN) and oropharyngeal tonsils (OT) in European wild boar naturally infected with Mycobacterium bovis. Genomics and proteomics data were used to compare differential gene expression and global protein patterns in OT and MLN of M. bovis-infected and uninfected European wild boar and the results were analyzed considering previous reports of experimental infections in laboratory and domestic animals. The results showed tissue-specific differences in OT and MLN in response to M. bovis infection. Tissue-specific differences in gene expression and protein profiles suggested different functions for OT and MLN during mycobacterial infection and provided information to characterize the pathobiology of M. bovis infection in European wild boar with important implications for the control of bTB in Spain. The characterization of molecular events in tissues that play different roles during mycobacterial infection in naturally infected individuals may be relevant to understand the pathobiology of M. bovis infection and to design effective strategies for the control of bTB in wildlife reservoirs.
牛结核病（bTB）是一种已确认的人畜共患病，影响着全球的牛和野生动物，因此需要新的策略来控制和根除这种疾病。欧洲野猪（Sus scrofa）是西班牙牛结核病的主要宿主。本文的目的是综述自然感染牛分枝杆菌的欧洲野猪下颌淋巴结（MLN）和口咽扁桃体（OT）的组织特异性反应和功能。利用基因组学和蛋白质组学数据比较感染和未感染牛分枝杆菌的欧洲野猪OT和MLN中的差异基因表达和整体蛋白质模式，并结合先前关于实验室动物和家畜实验感染的报告对结果进行分析。结果显示，OT和MLN对牛分枝杆菌感染的反应存在组织特异性差异。基因表达和蛋白质谱的组织特异性差异表明，在分枝杆菌感染期间，OT和MLN具有不同的功能，为了解西班牙牛结核病的发病机制提供了重要信息，对控制牛结核病具有重要意义。在自然感染个体中，分枝杆菌感染期间发挥不同作用的组织中分子事件的特征，可能有助于理解牛分枝杆菌感染的发病机制，并设计出控制野生动物宿主中牛结核病的有效策略。
