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用于治疗癌症患者的细胞保护剂。

Cytoprotective agents used in the treatment of patients with cancer.

作者信息

Hogle William P

机构信息

UPMC Passavant Cancer Center, Pittsburgh, PA, USA.

出版信息

Semin Oncol Nurs. 2007 Aug;23(3):213-24. doi: 10.1016/j.soncn.2007.05.006.

DOI:10.1016/j.soncn.2007.05.006
PMID:17693348
Abstract

OBJECTIVE

To provide a review of the literature of commonly prescribed cytoprotective agents used in the treatment of patients with cancer.

DATA SOURCES

Journal articles, research reports, review articles, and web sites.

CONCLUSION

Multiple agents have been theorized to have cytoprotective properties. Significant evidence exists supporting the use of some cytoprotective agents approved by the US Food and Drug Administration (FDA). More research is needed to determine the efficacy of new cytoprotective agents and expanded indications for those agents currently used.

IMPLICATIONS FOR NURSING PRACTICE

Knowledge of the indications for and side effect profiles of cytoprotective agents is a necessary component of oncology nursing care. Familiarity with evidence-based research that supports or refutes the use of FDA-approved cytoprotective agents or alternative agents is helpful when suggesting, prescribing, or administering such agents.

摘要

目的

综述常用于治疗癌症患者的细胞保护剂的文献。

资料来源

期刊文章、研究报告、综述文章及网站。

结论

多种药物被认为具有细胞保护特性。有大量证据支持使用美国食品药品监督管理局(FDA)批准的一些细胞保护剂。需要更多研究来确定新型细胞保护剂的疗效以及扩大目前所用药物的适应证。

对护理实践的启示

了解细胞保护剂的适应证和副作用概况是肿瘤护理的必要组成部分。在建议、开处方或使用此类药物时,熟悉支持或反驳使用FDA批准的细胞保护剂或替代药物的循证研究很有帮助。

相似文献

1
Cytoprotective agents used in the treatment of patients with cancer.用于治疗癌症患者的细胞保护剂。
Semin Oncol Nurs. 2007 Aug;23(3):213-24. doi: 10.1016/j.soncn.2007.05.006.
2
[Development of cancer chemotherapy. Cytoprotective agents].[癌症化疗的发展。细胞保护剂]
Clin Ter. 2001 Mar-Apr;152(2):135-43.
3
American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants.美国临床肿瘤学会2008年临床实践指南更新:化疗和放疗防护剂的使用
J Clin Oncol. 2009 Jan 1;27(1):127-45. doi: 10.1200/JCO.2008.17.2627. Epub 2008 Nov 17.
4
American Society of Clinical Oncology clinical practice guidelines for the use of chemotherapy and radiotherapy protectants.美国临床肿瘤学会关于化疗和放疗保护剂使用的临床实践指南。
J Clin Oncol. 1999 Oct;17(10):3333-55. doi: 10.1200/JCO.1999.17.10.3333.
5
Current role of chemotherapy protectors in cancer treatment.化疗保护剂在癌症治疗中的当前作用。
Bol Asoc Med P R. 1997 Oct-Dec;89(10-12):184-8.
6
Amifostine: drug profile and nursing implications of the first pancytoprotectant.氨磷汀:首个全血细胞保护剂的药物简介及护理要点
Oncol Nurs Forum. 1998 Apr;25(3):515-23.
7
2002 update of recommendations for the use of chemotherapy and radiotherapy protectants: clinical practice guidelines of the American Society of Clinical Oncology.化疗与放疗防护剂使用建议的2002年更新:美国临床肿瘤学会临床实践指南
J Clin Oncol. 2002 Jun 15;20(12):2895-903. doi: 10.1200/JCO.2002.04.178.
8
Future directions in gynecologic cancer.妇科癌症的未来发展方向
Semin Oncol. 1999 Apr;26(2 Suppl 7):125-8.
9
The effect of cytoprotective agents in platinum anticancer therapy.细胞保护剂在铂类抗癌治疗中的作用。
Met Ions Biol Syst. 2004;42:179-208.
10
Recent developments and emerging options: the role of amifostine as a broad-spectrum cytoprotective agent.最新进展与新出现的选择:氨磷汀作为一种广谱细胞保护剂的作用
Semin Oncol. 1999 Apr;26(2 Suppl 7):1-2.

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