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1
Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens.新型隐球菌及其他人类病原体中葡糖神经酰胺的生物合成与免疫原性
Eukaryot Cell. 2007 Oct;6(10):1715-26. doi: 10.1128/EC.00208-07. Epub 2007 Aug 10.
2
Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection.抗真菌葡糖神经酰胺单克隆抗体可保护小鼠免受新型隐球菌致死性感染。
Clin Vaccine Immunol. 2007 Oct;14(10):1372-6. doi: 10.1128/CVI.00202-07. Epub 2007 Aug 22.
3
Depletion of alveolar macrophages decreases the dissemination of a glucosylceramide-deficient mutant of Cryptococcus neoformans in immunodeficient mice.肺泡巨噬细胞的消耗会减少新型隐球菌葡糖神经酰胺缺陷型突变体在免疫缺陷小鼠中的传播。
Infect Immun. 2007 Oct;75(10):4792-8. doi: 10.1128/IAI.00587-07. Epub 2007 Jul 30.
4
Cryptococcus neoformans and cryptococcosis.新型隐球菌与隐球菌病
J Infect. 2000 Jul;41(1):12-7. doi: 10.1053/jinf.2000.0695.
5
Antibody-mediated effects against Cryptococcus neoformans: evidence for interdependency and collaboration between humoral and cellular immunity.抗新型隐球菌的抗体介导效应：体液免疫与细胞免疫之间相互依存及协作的证据
Res Immunol. 1998 May-Jun;149(4-5):321-33; discussion 500-3. doi: 10.1016/s0923-2494(98)80756-6.
6
An anti-beta-glucan monoclonal antibody inhibits growth and capsule formation of Cryptococcus neoformans in vitro and exerts therapeutic, anticryptococcal activity in vivo.一种抗β-葡聚糖单克隆抗体在体外可抑制新型隐球菌的生长和荚膜形成，并在体内发挥治疗性抗隐球菌活性。
Infect Immun. 2007 Nov;75(11):5085-94. doi: 10.1128/IAI.00278-07. Epub 2007 Jul 2.
7
Antibody to Cryptococcus neoformans glucuronoxylomannan inhibits the release of capsular antigen.新型隐球菌葡糖醛酸木聚糖甘露聚糖抗体可抑制荚膜抗原的释放。
Infect Immun. 2004 Jun;72(6):3674-9. doi: 10.1128/IAI.72.6.3674-3679.2004.
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Primary cutaneous cryptococcosis in a patient with minimal change nephrotic syndrome.一名患有微小病变型肾病综合征患者的原发性皮肤隐球菌病。
Nephrol Dial Transplant. 2005 Nov;20(11):2578-9. doi: 10.1093/ndt/gfi047. Epub 2005 Aug 2.
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Protective and nonprotective human immunoglobulin M monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan manifest different specificities and gene use profiles.针对新型隐球菌葡糖醛酸木聚糖甘露聚糖的保护性和非保护性人免疫球蛋白M单克隆抗体表现出不同的特异性和基因使用谱。
Infect Immun. 2004 Aug;72(8):4810-8. doi: 10.1128/IAI.72.8.4810-4818.2004.
10
Etiological factors of cryptococcosis - what makes them pathogens ?隐球菌病的病因——是什么使其成为病原体？
Med Dosw Mikrobiol. 2015;67(3-4):221-31.

引用本文的文献

1
Glycosphingolipids in Filamentous Fungi: Biological Roles and Potential Applications in Cosmetics and Health Foods.丝状真菌中的糖鞘脂：生物学作用及在化妆品和保健食品中的潜在应用
Front Microbiol. 2021 Jul 22;12:690211. doi: 10.3389/fmicb.2021.690211. eCollection 2021.
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Immunization Strategies for the Control of Histoplasmosis.控制组织胞浆菌病的免疫策略
Curr Trop Med Rep. 2019 Jun;6(2):35-41. doi: 10.1007/s40475-019-00172-3. Epub 2019 Mar 26.
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Membrane Sphingolipids Regulate the Fitness and Antifungal Protein Susceptibility of .膜鞘脂调节……的适应性和抗真菌蛋白敏感性 。 （注：原文最后“. ”后面似乎缺失了具体内容）
Front Microbiol. 2019 Apr 11;10:605. doi: 10.3389/fmicb.2019.00605. eCollection 2019.
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Current trends to control fungal pathogens: exploiting our knowledge in the host-pathogen interaction.控制真菌病原体的当前趋势：利用我们在宿主-病原体相互作用方面的知识。
Infect Drug Resist. 2018 Jul 3;11:903-913. doi: 10.2147/IDR.S170337. eCollection 2018.
5
A Predicted Mannoprotein Participates in Capsular Structure.一种预测的甘露糖蛋白参与荚膜结构。
mSphere. 2018 Apr 25;3(2). doi: 10.1128/mSphere.00023-18.
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Biological Roles Played by Sphingolipids in Dimorphic and Filamentous Fungi.鞘脂在二相和丝状真菌中的生物学作用。
mBio. 2018 May 15;9(3):e00642-18. doi: 10.1128/mBio.00642-18.
7
Plasma membrane lipids and their role in fungal virulence.质膜脂质及其在真菌毒力中的作用。
Prog Lipid Res. 2016 Jan;61:63-72. doi: 10.1016/j.plipres.2015.11.003. Epub 2015 Dec 15.
8
Transmembrane transporter expression regulated by the glucosylceramide pathway in Cryptococcus neoformans.新型隐球菌中由葡糖神经酰胺途径调控的跨膜转运蛋白表达
BMC Res Notes. 2015 Nov 16;8:681. doi: 10.1186/s13104-015-1613-y.
9
Challenges posed by extracellular vesicles from eukaryotic microbes.真核微生物细胞外囊泡带来的挑战。
Curr Opin Microbiol. 2014 Dec;22:73-8. doi: 10.1016/j.mib.2014.09.012.
10
Sterylglucoside catabolism in Cryptococcus neoformans with endoglycoceramidase-related protein 2 (EGCrP2), the first steryl-β-glucosidase identified in fungi.新型隐球菌中与内切糖神经酰胺酶相关蛋白2（EGCrP2）的甾醇糖苷分解代谢，EGCrP2是在真菌中鉴定出的首个甾醇-β-葡萄糖苷酶。
J Biol Chem. 2015 Jan 9;290(2):1005-19. doi: 10.1074/jbc.M114.616300. Epub 2014 Oct 31.

本文引用的文献

1
Sre1p, a regulator of oxygen sensing and sterol homeostasis, is required for virulence in Cryptococcus neoformans.Sre1p是一种氧感应和甾醇稳态的调节因子，是新生隐球菌致病力所必需的。
Mol Microbiol. 2007 May;64(3):614-29. doi: 10.1111/j.1365-2958.2007.05676.x.
2
Characterization of glycoinositolphosphoryl ceramide structure mutant strains of Cryptococcus neoformans.新型隐球菌糖基肌醇磷酸神经酰胺结构突变株的鉴定
Glycobiology. 2007 Jun;17(6):1-11C. doi: 10.1093/glycob/cwm030. Epub 2007 Mar 16.
3
Role of a CUF1/CTR4 copper regulatory axis in the virulence of Cryptococcus neoformans.CUF1/CTR4铜调节轴在新型隐球菌毒力中的作用
J Clin Invest. 2007 Mar;117(3):794-802. doi: 10.1172/JCI30006. Epub 2007 Feb 8.
4
Beta-glucosylceramide: a novel method for enhancement of natural killer T lymphoycte plasticity in murine models of immune-mediated disorders.β-葡萄糖神经酰胺：一种增强免疫介导疾病小鼠模型中自然杀伤性T淋巴细胞可塑性的新方法。
Gut. 2007 Jan;56(1):82-9. doi: 10.1136/gut.2006.095497.
5
Expression of antibodies directed to Paracoccidioides brasiliensis glycosphingolipids during the course of paracoccidioidomycosis treatment.巴西副球孢子菌糖鞘脂抗体在副球孢子菌病治疗过程中的表达
Clin Vaccine Immunol. 2007 Feb;14(2):150-6. doi: 10.1128/CVI.00285-06. Epub 2006 Nov 29.
6
Vesicular polysaccharide export in Cryptococcus neoformans is a eukaryotic solution to the problem of fungal trans-cell wall transport.新型隐球菌中的囊泡多糖输出是真菌跨细胞壁运输问题的一种真核解决方案。
Eukaryot Cell. 2007 Jan;6(1):48-59. doi: 10.1128/EC.00318-06. Epub 2006 Nov 17.
7
Phagosome extrusion and host-cell survival after Cryptococcus neoformans phagocytosis by macrophages.巨噬细胞吞噬新型隐球菌后吞噬体的排出与宿主细胞存活
Curr Biol. 2006 Nov 7;16(21):2161-5. doi: 10.1016/j.cub.2006.09.061.
8
Yeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function.酵母鞘脂类：生物合成、调控及功能研究的最新进展
Biochim Biophys Acta. 2007 Mar;1771(3):421-31. doi: 10.1016/j.bbalip.2006.08.005. Epub 2006 Aug 10.
9
The cryptococcal enzyme inositol phosphosphingolipid-phospholipase C confers resistance to the antifungal effects of macrophages and promotes fungal dissemination to the central nervous system.新型隐球菌的肌醇磷酸鞘脂 - 磷脂酶C赋予其对巨噬细胞抗真菌作用的抗性，并促进真菌向中枢神经系统播散。
Infect Immun. 2006 Oct;74(10):5977-88. doi: 10.1128/IAI.00768-06.
10
Cryptococcosis.隐球菌病
Infect Dis Clin North Am. 2006 Sep;20(3):507-44, v-vi. doi: 10.1016/j.idc.2006.07.001.

Biosynthesis and immunogenicity of glucosylceramide in Cryptococcus neoformans and other human pathogens.

作者信息

Rhome Ryan, McQuiston Travis, Kechichian Talar, Bielawska Alicja, Hennig Mirko, Drago Monica, Morace Giulia, Luberto Chiara, Del Poeta Maurizio

机构信息

Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

出版信息

Eukaryot Cell. 2007 Oct;6(10):1715-26. doi: 10.1128/EC.00208-07. Epub 2007 Aug 10.

DOI:10.1128/EC.00208-07
PMID:17693597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2043385/
Abstract
摘要