Sakr Carine J, Leonard Robin C, Kreckmann Kim H, Slade Martin D, Cullen Mark R
Yale University School of Medicine, New Haven, Connecticut, USA.
J Occup Environ Med. 2007 Aug;49(8):872-9. doi: 10.1097/JOM.0b013e318124a93f.
To examine the relationship between serum perfluorooctanoate (PFOA), a biomarker of ammonium perfluorooctanoate exposure, and lipids and liver enzymes.
We conducted a longitudinal study on 454 workers and used mixed models to examine the relationship between serum PFOA and lipids and liver enzymes.
One part per million (ppm) increase in serum PFOA was associated with a 1.06 mg/dL increase in total cholesterol, but was not associated with changes in triglycerides or other lipoproteins, after adjusting for potential confounders. Serum PFOA was also associated with total bilirubin (0.008 mg/dL decline/ppm) and serum aspartate aminotransferase (0.35 units increase/ppm) but not with the other liver enzymes.
These medical surveillance data collected on workers for up to 25 years contributes useful information on the effects of ammonium perfluorooctanoate exposure on human liver and lipid chemistry.
研究全氟辛酸铵暴露生物标志物血清全氟辛酸（PFOA）与脂质及肝酶之间的关系。
我们对454名工人进行了一项纵向研究，并使用混合模型来研究血清PFOA与脂质及肝酶之间的关系。
在调整潜在混杂因素后，血清PFOA每增加百万分之一（ppm），总胆固醇增加1.06mg/dL，但与甘油三酯或其他脂蛋白的变化无关。血清PFOA还与总胆红素（每ppm下降0.008mg/dL）和血清天冬氨酸转氨酶（每ppm增加0.35单位）有关，但与其他肝酶无关。
这些对工人长达25年收集的医学监测数据为全氟辛酸铵暴露对人体肝脏和脂质化学的影响提供了有用信息。
