Siproudhis L, Lescouarc'h J, Bretagne J F, Bourguet P, Raoul J L, Etienne P L, Herry J Y, Gosselin M
Service d'Hépato-Gastroentérologie, CHU Pontchaillou, Rennes.
Gastroenterol Clin Biol. 1991;15(11):789-93.
131I MIBG scintigraphy is of great value in the diagnosis and the treatment of several tumors derived from the neural crest. But, its role in the assessment of carcinoid tumors remains to be evaluated. It was the aim of this prospective study. Between 1987 and 1989, 14 consecutive patients with carcinoid tumors were studied. Planar scintigrams were obtained 24 and 48 hours after the intravenous injection of 74 MBq of 131I MIBG. At least one scintigraphy was performed in every patient; at that time one or several abdominal tumor sites (a total of 22 sites) were found and histologically proven. Scintigram was judged as positive in 9 of 14 patients (64 p. 100); 68 percent of the 22 tumor sites and 86 percent of the 14 extra-hepatic tumor sites took up 131I MIBG. Liver metastases were overlooked on scintigrams in 5 of 8 patients. Scintigraphy was the only positive examination in 3 patients. No false positive scintigrams were noticed. These results emphasize the value of 131I MIBG scintigraphy in the assessment of carcinoid value tumors.
131I间碘苄胍闪烁扫描术在诊断和治疗几种源自神经嵴的肿瘤方面具有重要价值。但其在类癌肿瘤评估中的作用仍有待评估。这是本前瞻性研究的目的。在1987年至1989年期间,对14例连续的类癌肿瘤患者进行了研究。在静脉注射74MBq的131I间碘苄胍后24小时和48小时获得平面闪烁扫描图。每位患者至少进行一次闪烁扫描;当时发现并经组织学证实了一个或几个腹部肿瘤部位(共22个部位)。14例患者中有9例(64%)闪烁扫描图被判定为阳性;22个肿瘤部位中的68%以及14个肝外肿瘤部位中的86%摄取了131I间碘苄胍。8例患者中有5例的肝转移在闪烁扫描图上被漏诊。闪烁扫描是3例患者唯一的阳性检查。未发现假阳性闪烁扫描图。这些结果强调了131I间碘苄胍闪烁扫描术在类癌肿瘤评估中的价值。