S100A10 expression in thyroid neoplasms originating from the follicular epithelium: contribution to the aggressive characteristic of anaplastic carcinoma.

BACKGROUND

S100A10, a member of the S100 family, forms a heterotetramer with annexin IIH and promotes carcinoma invasion and metastasis by plasminogen activation. In this study, S100A10 and annexin II expression in thyroid neoplasms were demonstrated.

PATIENTS AND METHODS

The expression levels of S100A10 and annexin II in 193 thyroid neoplasms were immunohistochemically investigated.

RESULTS

S10A10 and annexin II were not expressed in normal follicular cells or any follicular adenomas. Cells stained positively in 14.6% and 20.8% of follicular carcinomas for S100A10 and annexin II, respectively, but their expression levels were always low. S100A10 and annexin II were expressed in all papillary carcinomas, but 88.2% and 82.8% ofpapillary carcinomas were classified in the low group. These expression levels were not linked to any clinicopathological features. S100S10 and annexin II were also expressed in all anaplastic carcinomas, with 83.3% of these lesions were classified in the high group.

CONCLUSION

These findings suggest that S100A10 and annexin II contribute to the aggressive characteristics of anaplastic carcinoma, while playing a constitutive role in papillary carcinoma.