Discipline of Obstetrics and Gynaecology, Adelaide Medical School, Robinson Research Institute, The University of Adelaide, Adelaide 5005, Australia.
Department of Gynaecological Oncology, Royal Adelaide Hospital, Adelaide 5000, Australia.
Int J Mol Sci. 2018 Dec 19;19(12):4122. doi: 10.3390/ijms19124122.
S100A10, which is also known as p11, is located in the plasma membrane and forms a heterotetramer with annexin A2. The heterotetramer, comprising of two subunits of annexin A2 and S100A10, activates the plasminogen activation pathway, which is involved in cellular repair of normal tissues. Increased expression of annexin A2 and S100A10 in cancer cells leads to increased levels of plasmin-which promotes the degradation of the extracellular matrix-increased angiogenesis, and the invasion of the surrounding organs. Although many studies have investigated the functional role of annexin A2 in cancer cells, including ovarian cancer, S100A10 has been less studied. We recently demonstrated that high stromal annexin A2 and high cytoplasmic S100A10 expression is associated with a 3.4-fold increased risk of progression and 7.9-fold risk of death in ovarian cancer patients. Other studies have linked S100A10 with multidrug resistance in ovarian cancer; however, no functional studies to date have been performed in ovarian cancer cells. This article reviews the current understanding of S100A10 function in cancer with a particular focus on ovarian cancer.
S100A10 也被称为 p11，位于质膜上，并与 annexin A2 形成异四聚体。该异四聚体由 annexin A2 和 S100A10 的两个亚基组成，可激活纤溶酶原激活途径，该途径参与正常组织的细胞修复。癌细胞中 annexin A2 和 S100A10 的表达增加会导致纤溶酶水平升高-促进细胞外基质降解、血管生成增加以及周围器官的侵袭。尽管许多研究已经调查了 annexin A2 在包括卵巢癌在内的癌细胞中的功能作用，但 S100A10 的研究较少。我们最近表明，高基质 annexin A2 和高细胞质 S100A10 表达与卵巢癌患者进展风险增加 3.4 倍和死亡风险增加 7.9 倍相关。其他研究将 S100A10 与卵巢癌中的多药耐药性联系起来；然而，迄今为止尚未在卵巢癌细胞中进行任何功能研究。本文综述了 S100A10 在癌症中的功能的当前认识，特别关注卵巢癌。
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