Turban Sharon, Thuluvath Paul J, Atta Mohamed G
Division of Nephrology, Johns Hopkins University, 1830 East Monument Street, Suite 416, Baltimore, Maryland 21205, USA.
World J Gastroenterol. 2007 Aug 14;13(30):4046-55. doi: 10.3748/wjg.v13.i30.4046.
Hepatorenal syndrome (HRS) is a "functional" and reversible form of renal failure that occurs in patients with advanced chronic liver disease. The distinctive hallmark feature of HRS is the intense renal vasoconstriction caused by interactions between systemic and portal hemodynamics. This results in activation of vasoconstrictors and suppression of vasodilators in the renal circulation. Epidemiology, pathophysiology, as well as current and emerging therapies of HRS are discussed in this review.
肝肾综合征(HRS)是一种发生在晚期慢性肝病患者中的“功能性”且可逆的肾衰竭形式。HRS的显著标志性特征是全身和门静脉血流动力学相互作用导致的强烈肾血管收缩。这导致肾循环中血管收缩剂的激活和血管扩张剂的抑制。本文综述了HRS的流行病学、病理生理学以及当前和新出现的治疗方法。