大鼠T细胞对金黄色葡萄球菌肠毒素（SE）反应的遗传控制。
Genetic control of rat T-cell response to Staphylococcus aureus enterotoxins (SE).
作者信息
Fu Y, Villas P A, Blankenhorn E P
机构信息
Department of Microbiology and Immunology, Hahnemann University, Philadelphia, PA 19102.
出版信息
Immunology. 1991 Nov;74(3):484-9.
Rat T cells, like those of mouse and human origin, respond strongly to superantigens (SAg) derived from Staphylococcus aureus enterotoxins A and B (SEA, SEB). Lewis and ACI are high responders, whereas Brown Norway (BN) is a low responder. Congenic and back-cross rat studies indicate that the degree of responsiveness is controlled by at least one non-MHC gene. The action of these genes may reside in the antigen-presenting cells (APC), since both Sephadex G10 non-adherent BN spleen cells and purified BN T cells in the presence of Lewis APC can respond well to SE. Responses to concanavalin A (Con A) and SEA generally segregate together in back-cross rats. Surprisingly, the degree of responsiveness to Con A and SEA is not correlated with the susceptibility to experimental allergic encephalomyelitis (EAE) either in independently derived inbred rat strains or in (Lewis x BN) x BN back-cross rats.
大鼠T细胞与源自小鼠和人类的T细胞一样，对源自金黄色葡萄球菌肠毒素A和B（SEA、SEB）的超抗原（SAg）有强烈反应。Lewis和ACI是高反应者，而棕色挪威大鼠（BN）是低反应者。同基因和回交大鼠研究表明，反应程度至少由一个非MHC基因控制。这些基因的作用可能存在于抗原呈递细胞（APC）中，因为在Lewis APC存在的情况下，Sephadex G10非黏附性BN脾细胞和纯化的BN T细胞都能对SE产生良好反应。在回交大鼠中，对刀豆球蛋白A（Con A）和SEA的反应通常一起分离。令人惊讶的是，无论是在独立衍生的近交大鼠品系中，还是在（Lewis×BN）×BN回交大鼠中，对Con A和SEA的反应程度与实验性自身免疫性脑脊髓炎（EAE）的易感性均无关联。
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