Hofmeister Erik H, Mackey Elizabeth B, Trim Cynthia M
Department of Small Animal Medicine & Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Vet Anaesth Analg. 2008 Jan;35(1):38-44. doi: 10.1111/j.1467-2995.2007.00355.x. Epub 2007 Aug 13.
To determine cardiovascular responses to administration of butorphanol in isoflurane-anesthetized horses.
Retrospective evaluation of anesthetic records.
Seventy-six horses anesthetized for a variety of clinical surgical procedures.
Anesthetic records of clinical equine patients anesthetized between January 1999 and December 2003 were searched. The records were reviewed for horses in which anesthesia was induced with ketamine and a benzodiazepine and maintained with isoflurane, and horses that received butorphanol intraoperatively. Exclusion criteria included horses in which the rate of infusion of an inotrope or end-tidal isoflurane concentration was changed 10 minutes before or after the butorphanol bolus. The horses were separated into two groups: group 1 horses received butorphanol at intervals as part of a balanced protocol, group 2 horses had > or = 10% increase in heart rate (HR) or blood pressure within 10 minutes prior to butorphanol administration.
Eighty-nine butorphanol administration events matched the criteria for inclusion, 49 in group 1 and 40 in group 2. There were no significant changes after butorphanol administration in systolic arterial pressure (SAP), mean arterial pressure (MAP), diastolic arterial pressure (DAP), and heart rate (HR) in group 1, or in end-tidal carbon dioxide concentration or hemoglobin oxygen saturation in either group. There were significant decreases in SAP (p < 0.0001), MAP (p < 0.0005), and DAP (p < 0.0008) after butorphanol administration in group 2.
The results presented here confirm that butorphanol can be administered to horses during isoflurane anesthesia without adverse effects on HR and arterial blood pressure. The results imply that butorphanol can deepen the plane of anesthesia and obtund sympathetic stimulation from a surgical procedure.
确定布托啡诺对异氟烷麻醉马匹心血管系统的影响。
对麻醉记录进行回顾性评估。
76匹因各种临床手术而接受麻醉的马匹。
检索1999年1月至2003年12月期间临床马科动物患者的麻醉记录。对使用氯胺酮和苯二氮䓬诱导麻醉并使用异氟烷维持麻醉的马匹，以及术中接受布托啡诺的马匹的记录进行审查。排除标准包括在布托啡诺推注前或后10分钟内改变了强心剂输注速率或呼气末异氟烷浓度的马匹。将马匹分为两组：第1组马匹按平衡方案间隔接受布托啡诺，第2组马匹在给予布托啡诺前10分钟内心率（HR）或血压升高≥10%。
89次布托啡诺给药事件符合纳入标准，第1组49次，第2组40次。第1组布托啡诺给药后，收缩压（SAP）、平均动脉压（MAP）、舒张压（DAP）和心率（HR）无显著变化，两组的呼气末二氧化碳浓度或血红蛋白氧饱和度也无显著变化。第2组布托啡诺给药后，SAP（p<0.0001）、MAP（p<0.0005）和DAP（p<0.0008）显著下降。
此处呈现的结果证实，在异氟烷麻醉期间可向马匹给予布托啡诺，而不会对HR和动脉血压产生不良影响。结果表明，布托啡诺可加深麻醉平面并减轻手术过程中的交感神经刺激。
