van Stralen K J, Le Cessie S, Rosendaal F R, Doggen C J M
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
J Thromb Haemost. 2007 Nov;5(11):2186-92. doi: 10.1111/j.1538-7836.2007.02732.x. Epub 2007 Aug 14.
Stasis of the blood has been postulated as a major cause of venous thrombosis. However, little is known about the effect of stimulating the blood flow in order to prevent venous thrombosis through, for example, sports activities.
In a large population-based case-control study (MEGA study), we studied whether participating in sports activities on a regular basis was associated with venous thrombosis risk.
PATIENTS/METHODS: Consecutive patients with a first venous thrombosis of the leg or a pulmonary embolism, and control subjects, consisting of partners of the patients and randomly selected control subjects from the general population, were asked to participate. Sports activities and other risk factors for venous thrombosis were reported in a standardized mailed questionnaire. Participants with malignancy were excluded.
Out of 3608 patients, 1136 (31.5%), and of our 4252 control subjects 1686 (39.7%), participated in sports activities. Participating in sports activities reduced the risk of venous thrombosis compared with not participating in sports activities [odds ratio (OR) 0.64; 95% CI 0.58-0.71]. Risk reductions were similar after adjustment for sex, age and body mass index (OR(adj) 0.71; 95% CI 0.64-0.78) and when the analysis was restricted to healthy individuals (OR(adj) 0.67; 95% CI 0.58-0.78). No differences in risk were found for various frequencies, intensities and types of sport.
Regular sports activities reduce the risk of venous thrombosis.
血液淤滞被认为是静脉血栓形成的主要原因。然而，关于通过体育活动等方式刺激血流以预防静脉血栓形成的效果，人们了解甚少。
在一项基于大人群的病例对照研究（MEGA研究）中，我们研究了定期参加体育活动是否与静脉血栓形成风险相关。
患者/方法：连续纳入首次发生腿部静脉血栓或肺栓塞的患者，以及对照者，对照者包括患者的配偶和从普通人群中随机选取的对照对象，邀请他们参与研究。通过标准化邮寄问卷报告体育活动及其他静脉血栓形成的危险因素。排除患有恶性肿瘤的参与者。
在3608例患者中，1136例（31.5%）参加了体育活动；在4252例对照者中，1686例（39.7%）参加了体育活动。与不参加体育活动相比，参加体育活动可降低静脉血栓形成风险[比值比（OR）0.64；95%可信区间（CI）0.58 - 0.71]。在对性别、年龄和体重指数进行校正后，风险降低情况相似（校正后OR 0.71；95% CI 0.64 - 0.78），且当分析仅限于健康个体时也是如此（校正后OR 0.67；95% CI 0.58 - 0.78）。不同频率、强度和类型的运动在风险方面未发现差异。
定期体育活动可降低静脉血栓形成风险。
