Prandoni P
Department of Medical and Surgical Sciences, Thromboembolism Unit, University Hospital of Padua, Padua, Italy.
J Intern Med. 2007 Sep;262(3):341-50. doi: 10.1111/j.1365-2796.2007.01815.x.
An increasing body of evidence suggests the likelihood of a link between arterial and venous disease. According to the results of recent studies, atherosclerosis and venous thromboembolism (VTE) share common risk factors, including age, obesity, diabetes mellitus and metabolic syndrome. Atherosclerosis has the potential to promote the development of thrombotic disorders in the venous system. Another scenario assumes that the two clinical conditions are simultaneously triggered by biological stimuli responsible for activating coagulation and inflammatory pathways in both the arterial and the venous system. Several recent studies have consistently shown that patients with VTE of unknown origin are at a higher risk of cardiovascular diseases, including atherosclerotic complications, than patients with secondary VTE and matched control individuals. Future studies are needed to clarify the nature of this association, to assess its extent and to evaluate its implications for clinical practice.
越来越多的证据表明动脉疾病和静脉疾病之间可能存在联系。根据最近的研究结果，动脉粥样硬化和静脉血栓栓塞（VTE）具有共同的风险因素，包括年龄、肥胖、糖尿病和代谢综合征。动脉粥样硬化有可能促进静脉系统中血栓形成性疾病的发展。另一种情况是，这两种临床病症是由负责激活动脉和静脉系统中凝血和炎症途径的生物刺激同时引发的。最近的几项研究一致表明，不明原因VTE患者比继发性VTE患者和匹配的对照个体患心血管疾病（包括动脉粥样硬化并发症）的风险更高。需要进一步的研究来阐明这种关联的性质，评估其程度，并评估其对临床实践的影响。
