Department of Cardiothoracic and Vascular Sciences, Clinica Medica II and Thromboembolism Unit, University Hospital of Padua, Via Giustiniani 2, Padua, Italy.
Semin Respir Crit Care Med. 2012 Apr;33(2):205-10. doi: 10.1055/s-0032-1311801. Epub 2012 May 30.
An increasing body of evidence suggests the likelihood of a link between venous and arterial thrombosis. The two vascular complications share several risk factors, such as age, obesity, smoking, diabetes mellitus, blood hypertension, hypertriglyceridemia, and metabolic syndrome. Moreover, there are many examples of conditions accounting for both venous and arterial thrombosis, such as the antiphospholipid antibody syndrome, hyperhomocysteinemia, malignancies, infections, and the use of hormonal treatment. Finally, several recent studies have consistently shown that patients with venous thromboembolism are at a higher risk of arterial thrombotic complications than matched control individuals. We, therefore, speculate the two vascular complications are simultaneously triggered by biological stimuli responsible for activating coagulation and inflammatory pathways in both the arterial and the venous system. Future studies are needed to clarify the nature of this association, to assess its extent, and to evaluate its implications for clinical practice.
越来越多的证据表明静脉血栓形成和动脉血栓形成之间存在关联的可能性。这两种血管并发症有几个共同的危险因素，如年龄、肥胖、吸烟、糖尿病、高血压、高三酰甘油血症和代谢综合征。此外，还有许多同时导致静脉和动脉血栓形成的疾病，如抗磷脂抗体综合征、高同型半胱氨酸血症、恶性肿瘤、感染和激素治疗。最后，几项最近的研究一致表明，静脉血栓栓塞患者发生动脉血栓性并发症的风险高于匹配的对照组个体。因此，我们推测这两种血管并发症是由同时触发的生物刺激引起的，这些刺激负责激活动脉和静脉系统中的凝血和炎症途径。需要进一步的研究来阐明这种关联的性质，评估其程度，并评估其对临床实践的影响。
