Franchini Massimo, Mannucci Pier Mannuccio
Transfusion and Hemophilia Center, City Hospital of Verona, Italy.
Eur J Intern Med. 2008 Nov;19(7):476-81. doi: 10.1016/j.ejim.2007.10.019. Epub 2008 Mar 20.
Until recently venous and arterial thrombosis were considered mechanistically distinct entities. However, their separate nature has been challenged by several studies showing that these conditions share a number of risk factors such as age, obesity, infections and the metabolic syndrome. The existence of an association is further supported by the finding that patients with venous thromboembolism are at higher risk of arterial events and vice versa. This review article addresses the association between venous and arterial thrombosis and its clinical and therapeutic implications. We conclude that arterial and venous thrombosis are mechanistically different, but that common risk factors are more relevant and frequent than previously thought.
直到最近，静脉血栓形成和动脉血栓形成在机制上仍被视为不同的实体。然而，它们各自独立的性质受到了多项研究的挑战，这些研究表明，这些病症存在一些共同的风险因素，如年龄、肥胖、感染和代谢综合征。静脉血栓栓塞患者发生动脉事件的风险更高，反之亦然，这一发现进一步支持了两者之间关联的存在。这篇综述文章探讨了静脉血栓形成和动脉血栓形成之间的关联及其临床和治疗意义。我们得出的结论是，动脉血栓形成和静脉血栓形成在机制上有所不同，但共同的风险因素比以前认为的更为相关和常见。
