Chen Jennifer, Lee Lawrence
City Eye Centre, School of Optometry and Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
Clin Exp Optom. 2007 Sep;90(5):317-35. doi: 10.1111/j.1444-0938.2007.00151.x.
Optical coherence tomography (OCT) is a new imaging modality that has increasingly become an indispensable tool in clinical practice for the diagnosis and management of ocular diseases involving the macula, optic nerve and anterior segment. The instrument is an advanced imaging technique that provides unprecedented high resolution and cross-sectional tomographic images of the ocular microstructure in situ, and in real time. Since its introduction about four years ago, a multitude of advantages has made OCT an essential instrument in ophthalmic imaging. The technique has fast image acquisition speed and non-contact, non-invasive applicability, allowing a non-excisional 'optical biopsy' to be performed. The purpose of this paper is to provide an evidence-based review of the increasing role of OCT in the diagnosis and management of ocular disorders, particularly in age-related macular degeneration, diabetic macular oedema, macular hole, epiretinal membrane and glaucoma. Being one of the first users of OCT in Australia, our clinical experiences will be highlighted and clinical examples of various conditions will be presented to provide an overview of the immense implications of OCT in practice. The latest developments of the OCT revolution, in relation to combining OCT with fundus photography and scanning laser ophthalmoscopy, will also be described. New developments of three-dimensional visualisation of tissue morphology with future models of ultra-high speed, ultra-high resolution OCT may further enhance the early diagnosis, monitoring of disease progression and assessment of treatment efficacy, facilitated by this powerful technology.
光学相干断层扫描（OCT）是一种新型成像方式，在涉及黄斑、视神经和眼前节的眼部疾病的临床诊断和管理中，已日益成为不可或缺的工具。该仪器是一种先进的成像技术，能够原位实时提供眼部微观结构前所未有的高分辨率横断面断层图像。自大约四年前问世以来，众多优势使OCT成为眼科成像的重要仪器。该技术具有快速的图像采集速度以及非接触、非侵入性的适用性，允许进行非切除性的“光学活检”。本文旨在对OCT在眼部疾病诊断和管理中日益重要的作用进行循证综述，尤其是在年龄相关性黄斑变性、糖尿病性黄斑水肿、黄斑裂孔、视网膜前膜和青光眼方面。作为澳大利亚最早使用OCT的用户之一，我们将重点介绍临床经验，并展示各种病症的临床实例，以概述OCT在实际应用中的巨大意义。还将描述OCT革命的最新进展，即OCT与眼底摄影和扫描激光检眼镜的结合。借助这项强大技术，未来超高速、超高分辨率OCT模型对组织形态进行三维可视化的新进展，可能会进一步提高疾病的早期诊断、病情进展监测和治疗效果评估。
