Paganelli R, Fanales-Belasio E, Carmini D, Scala E, Meglio P, Businco L, Aiuti F
Department of Allergy and Clinical Immunology, University La Sapienza, Rome, Italy.
Int Arch Allergy Appl Immunol. 1991;96(2):175-8. doi: 10.1159/000235490.
Atopic dermatitis (AD) is a chronic inflammatory disease of the skin, frequently associated with a family history of atopy, raised serum IgE levels and other immunological abnormalities. Both eosinophils and their basic proteins have been detected in the skin lesions of AD patients. We measured the levels of eosinophil cationic protein (ECP) in sera of 24 children with AD and found them to be increased, compared to nonatopic controls, both children and adults. High ECP values were also obtained in 3 patients with the hyper-IgE syndrome. However, no direct relationship between IgE and ECP serum levels could be established. We found no correlation between serum ECP and the number of circulating eosinophils, suggesting that part of ECP was produced by cells infiltrating the tissues. Measurement of ECP might represent a noninvasive tool to assess the activity of AD in relation to eosinophil involvement in this disease.
特应性皮炎（AD）是一种慢性皮肤炎症性疾病，常与特应性家族史、血清IgE水平升高及其他免疫异常相关。在AD患者的皮肤病变中已检测到嗜酸性粒细胞及其碱性蛋白。我们检测了24例AD患儿血清中嗜酸性粒细胞阳离子蛋白（ECP）的水平，发现与非特应性对照（包括儿童和成人）相比有所升高。3例高IgE综合征患者的ECP值也较高。然而，无法确定IgE与血清ECP水平之间存在直接关系。我们发现血清ECP与循环嗜酸性粒细胞数量之间无相关性，这表明部分ECP是由浸润组织的细胞产生的。检测ECP可能是一种评估AD活动度与嗜酸性粒细胞在该疾病中参与情况的非侵入性工具。
