Czech W, Krutmann J, Schöpf E, Kapp A
Department of Dermatology, University of Freiburg, Germany.
Br J Dermatol. 1992 Apr;126(4):351-5. doi: 10.1111/j.1365-2133.1992.tb00677.x.
Atopic dermatitis (AD) is characterized by alterations in cellular and humoral immunity including elevated serum levels of IgE, IL-2 receptor (IL-2R) and eosinophil cationic protein (ECP). In order to evaluate the relevance of these serum parameters as indicators of disease activity, the concentrations of IgE, IL-2R and ECP were measured in serum samples of patients with an acute exacerbation of AD (n = 19) on admission to hospital and every 6 days up to discharge, and compared with those from normal non-atopic controls (n = 15). The severity of the disease in the AD patients was examined using an established clinical scoring system. On admission, AD patients showed significantly elevated serum levels of IgE, IL-2R and ECP compared with normal controls (P less than or equal to 0.0001). Clinical improvement was associated with a decrease of both the clinical score (P less than or equal to 0.001) and serum ECP levels (P less than or equal to 0.005). No significant changes in serum IgE and serum IL-2R were observed. In addition, there was a significant correlation between serum ECP and the clinical score (R = 0.67, P less than or equal to 0.001). These data indicate that serum ECP may be a helpful tool for monitoring disease activity in AD.
特应性皮炎（AD）的特征在于细胞免疫和体液免疫的改变，包括血清IgE、白细胞介素-2受体（IL-2R）和嗜酸性粒细胞阳离子蛋白（ECP）水平升高。为了评估这些血清参数作为疾病活动指标的相关性，对19例AD急性加重期患者入院时及直至出院每6天的血清样本中IgE、IL-2R和ECP的浓度进行了测定，并与15例正常非特应性对照者的样本进行比较。使用既定的临床评分系统检查AD患者的疾病严重程度。入院时，AD患者的血清IgE、IL-2R和ECP水平与正常对照相比显著升高（P≤0.0001）。临床改善与临床评分降低（P≤0.001）和血清ECP水平降低（P≤0.005）相关。未观察到血清IgE和血清IL-2R有显著变化。此外，血清ECP与临床评分之间存在显著相关性（R = 0.67，P≤0.001）。这些数据表明，血清ECP可能是监测AD疾病活动的有用工具。
