Wüthrich B, Kägi M K, Joller-Jemelka H
Department of Dermatology, University Hospital, Zurich, Switzerland.
Arch Dermatol Res. 1992;284(6):339-42. doi: 10.1007/BF00372036.
Levels of soluble IL-2 receptors, IL-6, soluble CD23, soluble CD14 and ECP (eosinophilic cationic protein) were measured as markers of T-cell, B-cell, monocyte and eosinophilic leucocyte activation in 26 patients with atopic dermatitis (AD) on admission to (A) and at discharge from (D) the Department of Dermatology in Zurich. The serum levels of sIL-2R, IL-6, sCD23, sCD14 and ECP were significantly elevated in AD patients in comparison with the normal values of healthy donors. A significant decrease in sIL-2R (p = 0.0093) and in sCD14 (p = 0.0134) levels was demonstrated between A and D, correlating with the improvement in the skin intensity score (SIS). In addition, a significant correlation of the sCD14 levels and the SIS at A was demonstrated (p = 0.0415). These results also incriminate monocytes in the pathogenesis of AD, indicating that, besides sIL-2R and ECP, SCD14 could also be a possible marker for the disease activity.
在苏黎世皮肤科收治（A）及出院（D）时，检测了26例特应性皮炎（AD）患者的可溶性白细胞介素-2受体、白细胞介素-6、可溶性CD23、可溶性CD14和嗜酸性粒细胞阳离子蛋白（ECP）水平，作为T细胞、B细胞、单核细胞和嗜酸性粒细胞活化的标志物。与健康供体的正常值相比，AD患者血清中可溶性白细胞介素-2受体（sIL-2R）、白细胞介素-6、可溶性CD23、可溶性CD14和ECP水平显著升高。在A和D之间，sIL-2R（p = 0.0093）和sCD14（p = 0.0134）水平显著降低，这与皮肤强度评分（SIS）的改善相关。此外，在A时sCD14水平与SIS之间存在显著相关性（p = 0.0415）。这些结果也表明单核细胞参与了AD的发病机制，提示除了sIL-2R和ECP外，SCD14也可能是该疾病活动的一个标志物。
