Peña de León Edilberto, Aguilar Gaytán Sandra Socorro, Suárez Mendoza Aldo Antonio, Reyes Terán Gustavo
Centro de Investigación en Enfermedades Infecciosas (CIENI), Servicio de Infectología, Instituto Nacional de Enfermedades Respiratorias (INER), México D.F., México.
Rev Panam Salud Publica. 2007 May;21(5):313-9. doi: 10.1590/s1020-49892007000400007.
To validate the Medical Outcomes Study HIV Health Survey (MOS-HIV) quality of life instrument for its application in clinical research in Mexico.
The data for this study were collected between April, 2002, and February, 2004. An expert committee combined two Spanish-language translations of the MOS-HIV questionnaire. The new questionnaire's feasibility was assessed in a group of 32 HIV-infected persons by measuring how long they took to complete the questionnaire and the numbers of items they left unanswered. The questionnaire was then applied to a group of 120 HIV-positive patients and to a control group of 102 HIV-negative individuals. The following questionnaire characteristics were evaluated: (1) internal reliability (Cronbach alpha coefficient), (2) discriminant validity (the receiver operating characteristic (ROC) curves derived from the scores of the two groups), and (3) convergent validity (the Spearman correlation coefficients for the scores of the HIV-positive patients on the 11 MOS-HIV dimensions and their scores on the analog visual scale of the European Quality of Life 5-Dimensional format (EQ-5D) questionnaire, a list of symptoms, the viral load, and the CD4 cell count).
The mean response time with the questionnaire was 10 minutes and 22 seconds, and the mean number of unanswered items was 0.62. With each of the 11 dimensions of the questionnaire, the Cronbach alpha coefficient was at least 0.75. The mean scores obtained by the two groups were different for 9 of the 11 dimensions, and the 95% confidence intervals of the areas under the ROC curves did not include the value of 0.5 for 8 of the dimensions. The absolute value of the Spearman correlation coefficient was less than 0.3 for the CD4 cell count and for the viral load, and it was greater than 0.3 for each dimension and the scores on the list of symptoms and on the analog visual scale of the EQ-5D questionnaire.
The MOS-HIV measure is valid for use in clinical research among HIV-infected persons in Mexico.
验证《医学结果研究艾滋病毒健康调查》（MOS-HIV）生活质量工具在墨西哥临床研究中的适用性。
本研究数据收集于2002年4月至2004年2月期间。一个专家委员会将MOS-HIV问卷的两个西班牙语译本进行了合并。通过测量32名艾滋病毒感染者完成问卷所需的时间以及未作答项目的数量，对新问卷的可行性进行了评估。随后，该问卷被应用于一组120名艾滋病毒阳性患者和一组102名艾滋病毒阴性个体组成的对照组。对以下问卷特征进行了评估：（1）内部信度（克朗巴哈α系数），（2）判别效度（两组得分得出的受试者工作特征（ROC）曲线），以及（3）聚合效度（艾滋病毒阳性患者在MOS-HIV的11个维度上的得分与他们在欧洲生活质量5维度量表（EQ-5D）问卷的模拟视觉量表、症状清单、病毒载量和CD4细胞计数上的得分之间的斯皮尔曼相关系数）。
问卷的平均回答时间为10分22秒，未作答项目的平均数量为0.62。问卷的11个维度中，每个维度的克朗巴哈α系数至少为0.75。两组在11个维度中的9个维度上获得的平均得分不同，并且8个维度的ROC曲线下面积的95%置信区间不包括0.5。CD4细胞计数和病毒载量的斯皮尔曼相关系数绝对值小于0.3，而每个维度与症状清单得分以及EQ-5D问卷模拟视觉量表得分之间的斯皮尔曼相关系数绝对值大于0.3。
MOS-HIV测量方法在墨西哥艾滋病毒感染者的临床研究中有效。
