Infectious Diseases & HIV Division, 5th Department of Internal Medicine, Evaggelismos General Hospital, Athens, Greece.
Qual Life Res. 2010 Mar;19(2):199-205. doi: 10.1007/s11136-009-9573-0.
This study was intended to present evidence for the reliability and validity of a Greek translation of the Medical Outcomes Study-HIV Health Survey (MOS-HIV).
Sample consisted of 154 HIV-positive men and women, regardless of disease stage, who are being followed at the department of Infectious Diseases of a tertiary hospital of Athens, Greece.
The translated Greek version of the MOS-HIV instrument, a brief, comprehensive 35-item health-related quality of life questionnaire, was used to assess ten dimensions of health including overall quality of life, pain, physical functioning, role functioning, social functioning, mental health, energy/fatigue, cognitive function, health distress, and health transition. Additional socio-demographic data and clinical parameters were also collected. Standard guidelines were followed for questionnaire translation to the Greek language. Internal consistency reliability using Cronbach's alpha and the range of measurement of the MOS-HIV subscales were examined. Convergent validity was further examined with the intercorrelations of subscales. ROC analysis was used to estimate the ability of the subscales to discriminate patients according to the characteristics of the disease [i.e. asymptomatic, symptomatic and AIDS, CD4+ lymphocyte count (<200 cells/mm(3) and >200 cells/mm(3))] and assess concurrent validity.
All the MOS-HIV scales exceeded the minimum reliability standard of 0.70. Physical functioning and health distress had the greatest reliability coefficient, equal to 0.87 and 0.88, respectively. Correlations among MOS-HIV scales were all significant. Physical functioning, pain, and physical health summary scales were significantly lower for AIDS patients compared to asymptomatic HIV+ individuals. All scales except for role functioning and health transition could discriminate well subjects with CD4+ lymphocyte count <200 cells/mm(3) and >200 cells/mm(3).
The Greek version of the MOS-HIV had good reliability and validity among patients with AIDS. Convergent and concurrent validity were generally confirmed. The MOS-HIV may be useful in assessing health-related quality of life in AIDS patients in Greece. Further research is needed for the evaluation of the Greek version of the MOS-HIV responsiveness to changes over time.
本研究旨在为希腊文版医疗结局研究 - HIV 健康调查量表（MOS-HIV）的信度和效度提供证据。
样本由 154 名 HIV 阳性男性和女性组成，无论疾病阶段如何，他们都在希腊雅典一家三级医院的传染病科接受随访。
使用经过翻译的希腊文版 MOS-HIV 仪器，这是一种简短的、全面的 35 项健康相关生活质量问卷，评估十个健康维度，包括总体生活质量、疼痛、身体功能、角色功能、社会功能、心理健康、能量/疲劳、认知功能、健康困扰和健康转变。还收集了额外的社会人口统计学数据和临床参数。问卷翻译成希腊语遵循了标准指南。使用 Cronbach's alpha 检验内部一致性信度，并检查 MOS-HIV 分量表的测量范围。通过分量表的相互关联进一步检验了收敛效度。ROC 分析用于根据疾病特征（即无症状、有症状和 AIDS、CD4+淋巴细胞计数（<200 个细胞/mm³ 和>200 个细胞/mm³））评估亚量表区分患者的能力，并评估同时效度。
所有 MOS-HIV 量表都超过了 0.70 的最低可靠性标准。身体功能和健康困扰的可靠性系数最大，分别为 0.87 和 0.88。MOS-HIV 量表之间的相关性均具有统计学意义。与无症状 HIV+个体相比，AIDS 患者的身体功能、疼痛和身体健康综合量表得分显著较低。除角色功能和健康转变量表外，所有量表都能很好地区分 CD4+淋巴细胞计数<200 个细胞/mm³和>200 个细胞/mm³的受试者。
希腊文版 MOS-HIV 在 AIDS 患者中具有良好的信度和效度。收敛效度和同时效度普遍得到证实。MOS-HIV 可能有助于评估希腊 AIDS 患者的健康相关生活质量。需要进一步研究评估希腊文版 MOS-HIV 对随时间变化的反应能力。
