Nikolaeva M A, Kolomiets O L, Levenbuk I S
Arkh Patol. 1975;37(6):24-9.
A parallel histoenzymatic and electron-microscopy study of the state of mitochondria in experimental viral cancerogenesis induced by adenovirus of monkeys SA7(C8) and virus of Rous sarcoma in soft tissues of hamster was carried out. It was shown that the earliest changes in the cell in the process of its tumorous transformation were those in mitochondria. The character of deposits of diformazin at an early stage of viral cancerogenesis corresponded to the trend to the linear arrangement of mitochondria and to initial phenomena of their swelling. Progressive swelling of mitochondria in the process of tumorous growth was established, which correlated with histochemically revealed changes in the relationships of a number of reduction-oxidation enzymes.
对由猴腺病毒SA7（C8）和劳斯肉瘤病毒诱导的实验性病毒致癌过程中，仓鼠软组织中线粒体状态进行了组织酶学和电子显微镜平行研究。结果表明，细胞在肿瘤转化过程中最早的变化发生在线粒体。病毒致癌早期二亚甲嗪沉积物的特征与线粒体线性排列趋势及线粒体肿胀的初始现象相一致。证实了肿瘤生长过程中线粒体的进行性肿胀，这与组织化学揭示的一些还原-氧化酶关系的变化相关。
