Ageenko A I, Avtandilov G G, Kruglova I S, Sviridova I K
Biull Eksp Biol Med. 1981 Jul;92(7):80-2.
Microspectrophotometry was used to study the activity of oxidative enzymes in the cortical and medullar regions of the thymus, in epithelial stromal cells of CBA mice at varying time of postnatal development and during induced virus cancerogenesis. It was shown that in the thymus of control animals, the activity of NAD-, NADP-diaphorases and beta OBDH reached maximum on the 30th day of postnatal development. The animals exposed to virus manifested a distinct lowering of the activity of the enzymes even in the latent period of cancerogenesis. Variations of the activity of the test enzymes during postnatal development of control animals and at varying time of cancerogenesis appear to be related to functional potencies of the thymus.
利用显微分光光度法研究了出生后不同发育阶段及诱导病毒致癌过程中，CBA小鼠胸腺皮质和髓质区域、上皮基质细胞中氧化酶的活性。结果表明，在对照动物的胸腺中，NAD -、NADP - 黄递酶和β - 羟丁酸脱氢酶的活性在出生后第30天达到最高。即使在致癌潜伏期，接触病毒的动物也表现出这些酶活性明显降低。对照动物出生后发育过程中以及致癌不同阶段测试酶活性的变化似乎与胸腺的功能状态有关。
