Donnelly S C, McLaughlin H, Bredin C P
Department of Pathology, University College, Dublin.
Ir J Med Sci. 1991 Sep;160(9):288-90. doi: 10.1007/BF02948415.
The period of prevalence, 1988 inclusive, of Allergic Bronchopulmonary Aspergillosis (ABPA) and Allergic Bronchopulmonary Candiasis (ABPC), the two most frequently reported forms of allergic Bronchopulmonary Mycosis (ABPM), was investigated in an Irish regional hospital respiratory medicine outpatients, catchment area population 536,000. ABPM was defined by the presence of a majority of seven criteria: asthma, eosinophilia, elevated IgE, antibodies to Aspergillus Fumigatus or Candida Albicans, immediate skin test reaction to either fungus, culture of either fungus in sputum, and otherwise unexplained transient or permanent lung field x-ray abnormalities. New referrals were investigated for ABPM if they had asthma and eosinophilia, or asthma and lung field x-ray abnormalities. Fourteen patients with ABPM were identified from a total of 1390 new referrals, a period prevalence of just over one per cent. It is concluded that (1) ABPM is a relatively common disorder in an Irish regional hospital respiratory medicine outpatient population and (2) ABPC constitutes a higher proportion of this disorder than previously considered.
在一家爱尔兰地区医院的呼吸内科门诊对1988年(含)以来变应性支气管肺曲霉病(ABPA)和变应性支气管肺念珠菌病(ABPC)这两种最常报告的变应性支气管肺真菌病(ABPM)的患病期进行了调查,该医院的服务人口为53.6万。ABPM的定义为具备以下七条标准中的多数:哮喘、嗜酸性粒细胞增多、IgE升高、针对烟曲霉或白色念珠菌的抗体、对任一真菌的速发型皮肤试验反应、痰中任一真菌的培养以及其他无法解释的短暂或永久性肺野X线异常。如果新转诊患者有哮喘和嗜酸性粒细胞增多,或有哮喘和肺野X线异常,则对其进行ABPM调查。在总共1390例新转诊患者中识别出14例ABPM患者,期间患病率略高于1%。得出的结论是:(1)ABPM在爱尔兰地区医院呼吸内科门诊人群中是一种相对常见的疾病;(2)ABPC在该疾病中所占比例高于此前的认识。