Krejsek J, Kopecký O
Oddĕlení klinické imunologie a alergologie FN, Hradec Králové.
Vnitr Lek. 1998 Jan;44(1):42-5.
Interactions between endothelial cells, adherence of endothelial cells to the molecules of extracellular matrix, adhesion of leukocytes and platelets to the activated endothelial cell lining are mediated by adhesion molecules belonging into four families: immunoglobulins, integrins, selectins, and cadherins. Adhesion interactions mediate intercellular signaling. Soluble forms of adhesion molecules modulate adhesion interactions. The determination of soluble adhesion molecules in blood is used for indirect evaluation of function or dysfunction of endothelial cells. It is possible to modulate abnormal function of endothelial cells using monoclonal antibodies against adhesion molecules.
内皮细胞之间的相互作用、内皮细胞与细胞外基质分子的黏附、白细胞和血小板与活化的内皮细胞衬里的黏附，均由属于四个家族的黏附分子介导：免疫球蛋白、整合素、选择素和钙黏着蛋白。黏附相互作用介导细胞间信号传导。黏附分子的可溶性形式调节黏附相互作用。测定血液中可溶性黏附分子可用于间接评估内皮细胞的功能或功能障碍。使用针对黏附分子的单克隆抗体可以调节内皮细胞的异常功能。
