组氨酸类似物靶向猪布鲁氏菌毒力因子组氨醇脱氢酶可导致该病原体在巨噬细胞内繁殖受到抑制。
Targeting of the Brucella suis virulence factor histidinol dehydrogenase by histidinol analogues results in inhibition of intramacrophagic multiplication of the pathogen.
作者信息
Joseph Pascale, Abdo Marie-Rose, Boigegrain Rose-Anne, Montero Jean-Louis, Winum Jean-Yves, Köhler Stephan
机构信息
Centre d'Etudes d'Agents Pathogènes et Biotechnologies pour la Santé (CPBS), CNRS-UM1-UM2, UMR 5236, Université Montpellier II, cc100, Place Eugène Bataillon, 34095, Montpellier Cedex, France.
出版信息
Antimicrob Agents Chemother. 2007 Oct;51(10):3752-5. doi: 10.1128/AAC.00572-07. Epub 2007 Aug 13.
Abstract
Brucella suis histidinol dehydrogenase (HDH) can be efficiently targeted by substrate analogues. The growth of this pathogen in minimal medium was inhibited and the multiplication in human macrophages was totally abolished in the presence of the drugs. These effects have been shown to be correlated with the previously described inhibition of Brucella HDH activity.
摘要
猪布鲁氏菌组氨酸醇脱氢酶（HDH）可被底物类似物有效靶向。在存在这些药物的情况下，该病原体在基本培养基中的生长受到抑制，并且在人巨噬细胞中的增殖完全被消除。这些作用已被证明与先前描述的对布鲁氏菌HDH活性的抑制相关。
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