Bell Lana M, Watts Katie, Siafarikas Aris, Thompson Alisha, Ratnam Nirubasini, Bulsara Max, Finn Judith, O'Driscoll Gerry, Green Daniel J, Jones Timothy W, Davis Elizabeth A
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Crawley, Western Australia 6009, Australia.
J Clin Endocrinol Metab. 2007 Nov;92(11):4230-5. doi: 10.1210/jc.2007-0779. Epub 2007 Aug 14.
The number of obese children with insulin resistance and type 2 diabetes is increasing, but the best management strategy is not clear.
The objective of this study was to assess the effect of a structured 8-wk exercise training program on insulin resistance and changes in body composition in obese children.
The study was 8 wk of structured supervised exercise intervention with outcome measures before and after the exercise period.
Fourteen obese children (12.70 +/- 2.32 yr; eight male, six female) with high fasting insulin levels were enrolled into the study.
INTERVENTION consisted of 8 wk of supervised circuit-based exercise training, composed of three fully supervised 1-h sessions per week.
Outcome measures were assessed pretraining program and posttraining program and included insulin sensitivity (euglycemic-hyperinsulinemic clamp studies), fasting insulin and glucose levels, body composition using dual energy x-ray absorptiometry scan, lipid profile, and liver function tests.
Insulin sensitivity improved significantly after 8 wk of training (M(lbm) 8.20 +/- 3.44 to 10.03 +/- 4.33 mg/kg.min, P < 0.05). Submaximal exercise heart rate responses were significantly lower following the training (P < 0.05), indicating an improvement in cardiorespiratory fitness. Dual energy x-ray absorptiometry scans revealed no differences in lean body mass or abdominal fat mass.
An 8-wk exercise training program increases insulin sensitivity in obese children, and this improvement occurred in the presence of increased cardiorespiratory fitness but is independent of measurable changes in body composition.
患有胰岛素抵抗和2型糖尿病的肥胖儿童数量正在增加，但最佳管理策略尚不清楚。
本研究的目的是评估一项为期8周的结构化运动训练计划对肥胖儿童胰岛素抵抗和身体成分变化的影响。
该研究为为期8周的结构化监督运动干预，并在运动期前后进行结果测量。
14名空腹胰岛素水平高的肥胖儿童（12.70±2.32岁；8名男性，6名女性）被纳入研究。
干预包括为期8周的基于循环训练的监督运动训练，每周由三个完全监督的1小时课程组成。
在训练前计划和训练后计划中评估结果测量，包括胰岛素敏感性（正常血糖-高胰岛素钳夹研究）、空腹胰岛素和葡萄糖水平、使用双能X线吸收法扫描的身体成分、血脂谱和肝功能测试。
训练8周后胰岛素敏感性显著改善（无脂肪体重的代谢清除率从8.20±3.44至10.03±4.33mg/kg·min，P<0.05）。训练后次最大运动心率反应显著降低（P<0.05），表明心肺适能有所改善。双能X线吸收法扫描显示去脂体重或腹部脂肪量无差异。
一项为期8周的运动训练计划可提高肥胖儿童的胰岛素敏感性，这种改善发生在心肺适能增加的情况下，但与身体成分的可测量变化无关。
