Soriano F, Edwards R, Greenwood D
Department of Microbiology, University Hospital, Queen's Medical Centre, Nottingham, UK.
J Antimicrob Chemother. 1991 Jul;28(1):55-60. doi: 10.1093/jac/28.1.55.
The susceptibility of the new cephamycin antibiotic, cefminox, to hydrolysis by various types of beta-lactamase produced by organisms of the Bacteroides fragilis group was compared with that of cefoxitin. Several enzymes were able to achieve complete hydrolysis of both drugs during overnight incubation, but no marked difference between the rates of inactivation of cefminox and cefoxitin was observed. Susceptibility of the cephamycins to crude extracts of beta-lactamases from the test strains of Bacteroides spp. did not correlate with the results of conventional minimum inhibitory concentration titrations. Possible reasons for these discrepancies are discussed.
