脆弱拟杆菌中β-内酰胺酶相关的头孢西丁耐药性转移
Transfer of beta-lactamase-associated cefoxitin resistance in Bacteroides fragilis.
作者信息
Cuchural G J, Tally F P, Storey J R, Malamy M H
出版信息
Antimicrob Agents Chemother. 1986 May;29(5):918-20. doi: 10.1128/AAC.29.5.918.
Abstract
A cefoxitin-resistant Bacteroides fragilis isolate, TAL 4170, which inactivates cefoxitin, was able to transfer beta-lactamase-mediated cefoxitin resistance to a susceptible B. fragilis recipient. Cefoxitin-resistant transconjugants acquired a new beta-lactamase with a pI of 8.1 and were able to inactivate cefoxitin and retransfer cefoxitin resistance. No plasmids were detected in the donor or transconjugants.
摘要
一株对头孢西丁耐药的脆弱拟杆菌分离株TAL 4170，可使头孢西丁失活，它能够将β-内酰胺酶介导的头孢西丁耐药性转移至一株敏感的脆弱拟杆菌受体菌。对头孢西丁耐药的接合子获得了一种新的pI为8.1的β-内酰胺酶，并且能够使头孢西丁失活并再次转移头孢西丁耐药性。在供体菌或接合子中均未检测到质粒。
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