Eley A, Greenwood D
J Med Microbiol. 1986 Feb;21(1):49-57. doi: 10.1099/00222615-21-1-49.
Susceptibilities to beta-lactam antibiotics and beta-lactamase content of two groups of Bacteroides strains were compared. Type cultures produced low levels of beta-lactamase and were susceptible to cefoxitin, latamoxef, imipenem and the combination of benzylpenicillin and clavulanic acid. Other Bacteroides strains that produced higher levels of beta-lactamase were generally less susceptible to these antibiotics; this resistance was more closely related to enzyme type than to the amount of enzyme present. The beta-lactamases produced by the test strains fell into three broad groups on the basis of antibiotic degradation and inhibitor profiles: those that inactivated benzylpenicillin, but not cefoxitin, latamoxef or imipenem, and were susceptible to inhibition by beta-lactamase inhibitors; those that hydrolysed benzylpenicillin, cefoxitin and latamoxef, but not imipenem, and which were less susceptible to inhibition by beta-lactamase inhibitors; an enzyme that inactivated all the antibiotics and was not inhibited by beta-lactamase inhibitors.
比较了两组拟杆菌菌株对β-内酰胺抗生素的敏感性和β-内酰胺酶含量。标准菌株产生低水平的β-内酰胺酶，对头孢西丁、拉氧头孢、亚胺培南以及苄青霉素与克拉维酸的组合敏感。其他产生较高水平β-内酰胺酶的拟杆菌菌株通常对这些抗生素较不敏感；这种耐药性与酶的类型比与酶的含量更密切相关。根据抗生素降解和抑制剂谱，测试菌株产生的β-内酰胺酶可分为三大类：一类能使苄青霉素失活，但不能使头孢西丁、拉氧头孢或亚胺培南失活，且对β-内酰胺酶抑制剂敏感；一类能水解苄青霉素头孢西丁和拉氧头孢，但不能水解亚胺培南，且对β-内酰胺酶抑制剂不太敏感；还有一种酶能使所有抗生素失活，且不受β-内酰胺酶抑制剂抑制。
