疾病持续时间决定犬瘟热病毒的神经毒力。
Disease duration determines canine distemper virus neurovirulence.
作者信息
Bonami François, Rudd Penny A, von Messling Veronika
机构信息
INRS-Institut Armand-Frappier, University of Quebec, 531 boulevard des Prairies, Laval, Quebec, Canada.
出版信息
J Virol. 2007 Nov;81(21):12066-70. doi: 10.1128/JVI.00818-07. Epub 2007 Aug 15.
Abstract
The Morbillivirus hemagglutinin (H) protein mediates attachment to the target cell. To evaluate its contribution to canine distemper virus neurovirulence, we exchanged the H proteins of the wild-type strains 5804P and A75 and assessed the pathogenesis of the chimeric viruses in ferrets. Both strains are lethal to ferrets; however, 5804P causes a 2-week disease without neurological signs, whereas A75 is associated with a longer disease course and neurological involvement. We observed that both H proteins supported neuroinvasion and the subsequent development of clinical neurological signs if given enough time, demonstrating that disease duration is the main neurovirulence determinant.
摘要
麻疹病毒血凝素（H）蛋白介导与靶细胞的附着。为评估其对犬瘟热病毒神经毒力的作用，我们交换了野生型毒株5804P和A75的H蛋白，并评估了嵌合病毒在雪貂中的发病机制。这两种毒株对雪貂均具有致死性；然而，5804P引起为期2周的疾病且无神经症状，而A75与更长的病程及神经受累相关。我们观察到，如果给予足够时间，两种H蛋白均支持神经侵袭及随后临床神经症状的出现，这表明病程长短是主要的神经毒力决定因素。
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