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大序列多态性可对具有祖传间隔寡核苷酸分型模式的结核分枝杆菌菌株进行分类。

Large sequence polymorphisms classify Mycobacterium tuberculosis strains with ancestral spoligotyping patterns.

作者信息

Flores Laura, Van Tran, Narayanan Sujatha, DeRiemer Kathryn, Kato-Maeda Midori, Gagneux Sebastien

机构信息

Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, USA.

出版信息

J Clin Microbiol. 2007 Oct;45(10):3393-5. doi: 10.1128/JCM.00828-07. Epub 2007 Aug 15.

DOI:10.1128/JCM.00828-07
PMID:17699643
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2045339/
Abstract

Genomic deletion analysis revealed that strains of Mycobacterium tuberculosis exhibiting spoligotyping patterns with almost all spacers present belong either to a strain lineage that includes the W-Beijing strain family or to the ancestral strain lineage of M. tuberculosis.

摘要

基因组缺失分析表明，结核分枝杆菌菌株若呈现几乎所有间隔区都存在的寡核苷酸分型模式，则要么属于包含W-北京菌株家族的菌株谱系，要么属于结核分枝杆菌的祖先菌株谱系。

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Large sequence polymorphisms classify Mycobacterium tuberculosis strains with ancestral spoligotyping patterns.大序列多态性可对具有祖传间隔寡核苷酸分型模式的结核分枝杆菌菌株进行分类。
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本文引用的文献

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Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development.结核分枝杆菌的全球系统发育地理学及其对结核病产品开发的影响。
Lancet Infect Dis. 2007 May;7(5):328-37. doi: 10.1016/S1473-3099(07)70108-1.
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The W-Beijing lineage of Mycobacterium tuberculosis overproduces triglycerides and has the DosR dormancy regulon constitutively upregulated.结核分枝杆菌的北京W株系甘油三酯产生过多，并且DosR休眠调控子持续上调。
J Bacteriol. 2007 Apr;189(7):2583-9. doi: 10.1128/JB.01670-06. Epub 2007 Jan 19.
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Molecular epidemiology of tuberculosis: current insights.结核病的分子流行病学：当前见解
Clin Microbiol Rev. 2006 Oct;19(4):658-85. doi: 10.1128/CMR.00061-05.
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Mycobacterium tuberculosis complex genetic diversity: mining the fourth international spoligotyping database (SpolDB4) for classification, population genetics and epidemiology.结核分枝杆菌复合群的遗传多样性：挖掘第四个国际间隔寡核苷酸分型数据库（SpolDB4）用于分类、群体遗传学和流行病学研究
BMC Microbiol. 2006 Mar 6;6:23. doi: 10.1186/1471-2180-6-23.
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Variable host-pathogen compatibility in Mycobacterium tuberculosis.结核分枝杆菌中宿主与病原体的可变兼容性。
Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2869-73. doi: 10.1073/pnas.0511240103. Epub 2006 Feb 13.
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Global phylogeny of Mycobacterium tuberculosis based on single nucleotide polymorphism (SNP) analysis: insights into tuberculosis evolution, phylogenetic accuracy of other DNA fingerprinting systems, and recommendations for a minimal standard SNP set.基于单核苷酸多态性（SNP）分析的结核分枝杆菌全球系统发育：对结核病进化的见解、其他DNA指纹识别系统的系统发育准确性以及最小标准SNP集的建议。
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Single-nucleotide polymorphism-based population genetic analysis of Mycobacterium tuberculosis strains from 4 geographic sites.基于单核苷酸多态性的来自4个地理区域的结核分枝杆菌菌株群体遗传学分析。
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Revisiting the evolution of Mycobacterium bovis.重新审视牛分枝杆菌的进化
J Bacteriol. 2005 Sep;187(18):6386-95. doi: 10.1128/JB.187.18.6386-6395.2005.
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Genomic deletions classify the Beijing/W strains as a distinct genetic lineage of Mycobacterium tuberculosis.基因组缺失将北京/W菌株归类为结核分枝杆菌的一个独特遗传谱系。
J Clin Microbiol. 2005 Jul;43(7):3185-91. doi: 10.1128/JCM.43.7.3185-3191.2005.
10
Silent nucleotide polymorphisms and a phylogeny for Mycobacterium tuberculosis.结核分枝杆菌的沉默核苷酸多态性与系统发育
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