Makino H, Nishimura S, Haramoto T, Yamasaki Y, Ikeda S, Ota Z
Third Department of Medicine, Okayama University Medical School, Japan.
J Diabet Complications. 1991 Apr-Sep;5(2-3):124-5. doi: 10.1016/0891-6632(91)90041-m.
The three-dimensional ultrastructural changes of the glomerular extracellular matrices in diabetic glomerulosclerosis were studied in acellular rat and human diabetic glomeruli by scanning electron microscopy. The mesangial matrix appeared as fenestrated septa with oval stomata between the glomerular capillaries in normal control specimens. In diabetic glomerulosclerosis, both in humans and rats, expansion of mesangial matrix and narrowing of the mesangial fenestrae were observed. A thin layer of the mesangial matrix extended into the peripheral glomerular basement membrane (GBM) subendothelially. Thickening of the GBM in diabetic nephropathy might be due to expansion of the mesangial matrix into the peripheral GBM.
通过扫描电子显微镜，对无细胞大鼠和人类糖尿病肾小球中糖尿病肾小球硬化症时肾小球细胞外基质的三维超微结构变化进行了研究。在正常对照标本中，系膜基质表现为肾小球毛细血管之间带有椭圆形小孔的有孔隔膜。在人类和大鼠的糖尿病肾小球硬化症中，均观察到系膜基质扩张和系膜窗孔变窄。一层薄的系膜基质在内皮下延伸至外周肾小球基底膜（GBM）。糖尿病肾病中GBM增厚可能是由于系膜基质向外周GBM扩张所致。
