Fornari Fernando, Callegari-Jacques Sidia M, Scussel Plácido J, Madalosso Luiz F, Barros Enrique F, Barros Sérgio G S
Sciences in Gastroenterology, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Eur J Gastroenterol Hepatol. 2007 Sep;19(9):783-7. doi: 10.1097/MEG.0b013e3282748ecf.
To evaluate the association between ineffective oesophageal motility and reflux oesophagitis controlling for hiatal hernia, hypotensive lower oesophageal sphincter and male sex in patients with gastro-oesophageal reflux disease.
A total of 387 patients with reflux disease (mean age, 46 years, 42% men) were consecutively selected from a database. All patients underwent upper endoscopy, oesophageal manometry and 24 h oesophageal pH-metry in accordance with a standardized protocol. Reflux disease was confirmed either by endoscopy (oesophagitis grade I-IV according to Savary-Miller) or by pH-metry (increased acid exposure). Hiatal hernia was diagnosed endoscopically, whereas ineffective oesophageal motility and hypotensive lower oesophageal sphincter were characterized during manometry testing. The association between ineffective oesophageal motility and reflux oesophagitis was assessed by logistic regression analysis.
A total of 166 patients with oesophagitis (mean age 45 years, 49% men) and 221 without oesophagitis (mean age 46 years, 37% men) were present. Prevalences of ineffective oesophageal motility, hiatal hernia, hypotensive lower oesophageal sphincter and male sex were significantly higher in patients with oesophagitis compared with those without oesophagitis (P<0.05). Ineffective oesophageal motility was independently associated with oesophagitis after multivariate logistic regression analysis (odds ratio=1.68; 95% confidence interval=1.04-2.70).
Ineffective oesophageal motility is associated with reflux oesophagitis, independently of hiatal hernia, hypotensive lower oesophageal sphincter and male sex.
在胃食管反流病患者中，评估无效食管动力与反流性食管炎之间的关联，同时控制食管裂孔疝、食管下括约肌压力降低和男性因素。
从数据库中连续选取387例反流病患者（平均年龄46岁，42%为男性）。所有患者均按照标准化方案接受上消化道内镜检查、食管测压和24小时食管pH监测。反流病通过内镜检查（根据Savary-Miller分级为I-IV级食管炎）或pH监测（酸暴露增加）确诊。食管裂孔疝通过内镜诊断，而无效食管动力和食管下括约肌压力降低在测压测试中进行特征描述。通过逻辑回归分析评估无效食管动力与反流性食管炎之间的关联。
共有166例食管炎患者（平均年龄45岁，49%为男性）和221例无食管炎患者（平均年龄46岁，37%为男性）。与无食管炎患者相比，食管炎患者中无效食管动力、食管裂孔疝、食管下括约肌压力降低和男性的患病率显著更高（P<0.05）。多因素逻辑回归分析后，无效食管动力与食管炎独立相关（比值比=1.68；95%置信区间=1.04-2.70）。
无效食管动力与反流性食管炎相关，独立于食管裂孔疝、食管下括约肌压力降低和男性因素。
