Montet Xavier, Pastor Catherine M, Vallée Jean-Paul, Becker Christoph D, Geissbuhler Antoine, Morel Denis R, Meda Paolo
Department of Radiology, Geneva University Hospital, Geneva, Switzerland.
Invest Radiol. 2007 Sep;42(9):652-8. doi: 10.1097/RLI.0b013e31805f445b.
The goal of this study was to determine whether iodinated liposomes are a suitable tracer for mice microvessel and liver imaging by preclinical computed tomography (CT).
Iodinated liposomes were evaluated for vessel and liver imaging. A first group of nude mice was imaged by micro-CT after i.v. injection of liposomes at 1 or 2 gI/kg body weight (b.w.) for intervals up to 24 hours. A second group of mice bearing liver micrometastases was imaged after injection of liposomes at 2 gI/kg b.w. for intervals up to 24 hours.
Vascular enhancements of 120 +/- 8 and 322 +/- 20 Hounsfield unit (HU) were obtained after injection of liposomes at 1 or 2 gI/kg b.w., respectively. This enhancement decreased with a blood half-life of 135 +/- 10 and 86 +/- 9 minutes, respectively. Liver enhancement of 157 +/- 5 and 235 +/- 23 HU were obtained after injection of iodinated liposomes at 1 and 2 gI/kg b.w., respectively. Liver micrometastases (250 microm) were detectable after injection of iodinated liposomes at 2 gI/kg b.w.
Iodinated liposomes are a suitable contrast agent for vessels and liver imaging by micro-CT allowing clear vascular enhancement and detection of small liver metastases.
本研究的目的是确定碘化脂质体是否是一种适用于通过临床前计算机断层扫描（CT）对小鼠微血管和肝脏进行成像的示踪剂。
对碘化脂质体进行血管和肝脏成像评估。第一组裸鼠在静脉注射1或2 gI/千克体重（b.w.）的脂质体后，通过微型CT进行长达24小时的间隔成像。第二组患有肝脏微转移的小鼠在注射2 gI/千克b.w.的脂质体后，进行长达24小时的间隔成像。
分别在注射1或2 gI/千克b.w.的脂质体后，获得的血管增强值为120±8和322±20亨氏单位（HU）。这种增强分别以135±10和86±9分钟的血液半衰期下降。分别在注射1和2 gI/千克b.w.的碘化脂质体后，获得的肝脏增强值为157±5和235±23 HU。在注射2 gI/千克b.w.的碘化脂质体后，可检测到肝脏微转移灶（250微米）。
碘化脂质体是一种适用于通过微型CT进行血管和肝脏成像的造影剂，可实现清晰的血管增强并检测到小的肝脏转移灶。
