Klessen Christian, Hein Patrick A, Huppertz Alexander, Voth Matthias, Wagner Moritz, Elgeti Thomas, Kroll Hannes, Hamm Bernd, Taupitz Matthias, Asbach Patrick
Department of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Invest Radiol. 2007 Sep;42(9):659-64. doi: 10.1097/RLI.0b013e318063c635.
To evaluate gadofosveset trisodium for first-pass magnetic resonance angiography (MRA) in the setting of whole-body MRA (WB-MRA).
Forty patients were examined using either 10 mL gadofosveset trisodium (n = 20) or 30 mL gadopentetate dimeglumine (n = 20), followed by arterial-phase imaging of 4 consecutive anatomic regions. Signal intensity was measured in 2 vessels per region. Relative contrast values (RC) were calculated. Arterial contrast, venous overlay, and image quality were rated by 2 radiologists. The Mann-Whitney U test was used to test for significance.
Compared with gadopentetate dimeglumine, gadofosveset trisodium enhanced imaging revealed higher RC values in 2 vessel regions, with the differences being significant in 3 of 4 vessel segments. Gadofosveset trisodium revealed lower RC values in 2 regions with significant differences in 2 segments. Qualitative evaluation revealed higher ratings for gadofosveset trisodium regarding all 3 criteria with significant differences in 2 regions.
Gadofosveset trisodium serves well for first-pass imaging in WB-MRA.
评估钆弗塞特三钠用于全身磁共振血管造影（WB-MRA）中的首次通过磁共振血管造影（MRA）。
40例患者分别使用10 mL钆弗塞特三钠（n = 20）或30 mL钆喷酸葡胺（n = 20）进行检查，随后对4个连续解剖区域进行动脉期成像。每个区域在2条血管中测量信号强度。计算相对对比值（RC）。由2名放射科医生对动脉对比、静脉重叠和图像质量进行评分。采用Mann-Whitney U检验进行显著性检验。
与钆喷酸葡胺相比，钆弗塞特三钠增强成像在2个血管区域显示出更高的RC值，在4个血管节段中的3个节段差异具有显著性。钆弗塞特三钠在2个区域显示出较低的RC值，在2个节段差异具有显著性。定性评估显示，钆弗塞特三钠在所有3项标准上的评分更高，在2个区域差异具有显著性。
钆弗塞特三钠在WB-MRA的首次通过成像中表现良好。
