通过营养干预降低n-6/n-3脂肪酸比例可提高健康受试者的脂联素浓度并促进脂肪酸氧化。

Nutritional intervention to reduce the n-6/n-3 fatty acid ratio increases adiponectin concentration and fatty acid oxidation in healthy subjects.

作者信息

Guebre-Egziabher F, Rabasa-Lhoret R, Bonnet F, Bastard J-P, Desage M, Skilton M R, Vidal H, Laville M

机构信息

Centre de Recherche en Nutrition Humaine Rhône-Alpes, Univ de Lyon, F-69008, France.

出版信息

Eur J Clin Nutr. 2008 Nov;62(11):1287-93. doi: 10.1038/sj.ejcn.1602857. Epub 2007 Aug 15.

DOI:10.1038/sj.ejcn.1602857

PMID:17700650

Abstract

BACKGROUND/OBJECTIVES: Consumption of n-3 polyunsaturated fatty acids (PUFA) has a favourable impact on inflammation and cardiovascular disease. However, the Western diet is characterized by a low n-3 PUFA intake and an imbalance in the n-6/n-3 PUFA ratio. Study the effect 10-week of diet modification to decrease the n-6/n-3 PUFA ratio on cardiovascular risk factors and resting energy expenditure.

SUBJECTS AND METHODS

Ten-week dietary intervention in 17 healthy subjects. Dietary intake, euglycemic hyperinsulinemic clamp, indirect calorimetry, lipid profile, hormones, inflammatory markers and erythrocyte membrane fatty acid composition were recorded before and at the end of the intervention. Comparisons are between baseline and post-treatment levels.

RESULTS

Dietary records of the linoleic acid/alpha-linolenic acid ratio (baseline: 32.2 (s.d. 3.7) vs post-intervention: 2.2 (s.d. 0.1), P<0.0001) and erythrocyte membrane fatty acid composition reflected good compliance. Dietary intervention was associated with significant reductions in TNF-alpha (baseline: 2.2 (s.d. 0.3), post-intervention: 1.5 (s.d. 0.3) pg/ml, P=0.01) and low-density lipoprotein-cholesterol (baseline: 2.5 (s.d. 0.2), post-intervention: 2.3 (s.d. 0.1) mmol/l, P=0.03) and increased adiponectin (baseline: 6.5 (s.d. 0.7), post-intervention: 7.6 (s.d. 0.6) microg/ml, P=0.02). Fasting lipid oxidation was increased (baseline: 0.7 (s.d. 0.1), post-intervention: 0.9 (s.d. 0.1) mg/kg x min, P=0.01), whereas glucose oxidation decreased in both fasting (baseline: 1.6 (s.d. 0.1), post-intervention: 1.3 (s.d. 0.1) mg/kg x min, P=0.02) and hyperinsulinaemic conditions (baseline: 3.6 (s.d. 0.1), post-intervention: 3.3 (s.d. 0.1) mg/kg x min, P=0.04). Insulin sensitivity was not affected by the intervention.

CONCLUSION

A decreased n-6/n-3 PUFA ratio can be achieved with simple dietary counselling, resulting in multiple, potentially favourable effects on the metabolic and inflammatory profiles.

摘要

背景/目的：摄入n-3多不饱和脂肪酸（PUFA）对炎症和心血管疾病有积极影响。然而，西方饮食的特点是n-3 PUFA摄入量低，且n-6/n-3 PUFA比例失衡。研究为期10周的饮食调整以降低n-6/n-3 PUFA比例对心血管危险因素和静息能量消耗的影响。

受试者与方法

对17名健康受试者进行为期10周的饮食干预。在干预前及干预结束时记录饮食摄入量、正常血糖高胰岛素钳夹试验、间接测热法、血脂谱、激素、炎症标志物及红细胞膜脂肪酸组成。比较基线水平与治疗后水平。

结果

亚油酸/α-亚麻酸比例的饮食记录（基线：32.2（标准差3.7），干预后：2.2（标准差0.1），P<0.0001）及红细胞膜脂肪酸组成反映出良好的依从性。饮食干预与肿瘤坏死因子-α（TNF-α）显著降低（基线：2.2（标准差0.3），干预后：1.5（标准差0.3）pg/ml，P=0.01）、低密度脂蛋白胆固醇（基线：2.5（标准差0.2），干预后：2.3（标准差0.1）mmol/l，P=0.03）以及脂联素升高（基线：6.5（标准差0.7），干预后：7.6（标准差0.6）μg/ml，P=0.02）相关。空腹脂质氧化增加（基线：0.7（标准差0.1），干预后：0.9（标准差0.1）mg/kg·min，P=0.01），而空腹及高胰岛素状态下葡萄糖氧化均降低（空腹：基线：1.6（标准差0.1），干预后：1.3（标准差0.1）mg/kg·min，P=0.02；高胰岛素状态：基线：3.6（标准差0.1）,干预后：3.3（标准差0.1）mg/kg·min，P=0.04）。胰岛素敏感性未受干预影响。