Gonzalez-Becerra Karina, Barron-Cabrera Elisa, Muñoz-Valle Jose F, Torres-Castillo Nathaly, Rivera-Valdes Juan J, Rodriguez-Echevarria Roberto, Martinez-Lopez Erika
Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara, Av. Universidad 1115, Ocotlán 47810, Jalisco, Mexico.
Facultad de Ciencias de la Nutrición y Gastronomía, Universidad Autónoma Sinaloa, Av Cedros y Calle Sauces S/N, Culiacán 80010, Sinaloa, Mexico.
Healthcare (Basel). 2023 Aug 18;11(16):2333. doi: 10.3390/healthcare11162333.
The n-3 polyunsaturated fatty acids (PUFAs) can reduce inflammatory markers and may therefore be useful in obesity management. The aim of this study was to analyze the effect of supplementation with n-3 PUFAs on total fatty acid profile in red blood cells (RBCs), as well as biochemical and inflammatory markers, in subjects with obesity. The study consisted in a randomized placebo-controlled, double-blind clinical trial involving 41 subjects with obesity during a 4-month follow-up. Individuals were randomly assigned to two groups: n-3 PUFA supplementation (1.5 g fish oil) and placebo (1.5 g sunflower oil). Anthropometric, biochemical, dietetic, cytokine and total fatty acid profiles in RBCs were measured. Both groups increased their PUFA intake and DHA incorporation in RBCs. However, the placebo group showed a reduction in serum IL-8 and MCP-1 at the end of the study. A multiple linear regression model adjusted by body fat mass and sex showed that an increase in DHA in RBCs decreased the serum IL-8 levels in both study groups at the end of the study. Our results highlight the role of dietary DHA and n-3 supplementation usefulness in exerting beneficial anti-inflammatory effects.
n-3多不饱和脂肪酸（PUFAs）可降低炎症标志物水平，因此可能有助于肥胖管理。本研究旨在分析补充n-3 PUFAs对肥胖受试者红细胞（RBCs）总脂肪酸谱以及生化和炎症标志物的影响。该研究为一项随机、安慰剂对照、双盲临床试验，对41名肥胖受试者进行了为期4个月的随访。个体被随机分为两组：n-3 PUFA补充组（1.5 g鱼油）和安慰剂组（1.5 g葵花籽油）。测量了人体测量学、生化、饮食、细胞因子和RBCs中的总脂肪酸谱。两组均增加了PUFA摄入量以及RBCs中DHA的掺入量。然而，在研究结束时，安慰剂组的血清IL-8和MCP-1水平有所降低。经身体脂肪量和性别调整的多元线性回归模型显示，在研究结束时，RBCs中DHA的增加降低了两个研究组的血清IL-8水平。我们的结果突出了膳食DHA和n-3补充剂在发挥有益抗炎作用方面的作用。
