Torres Carlos, Khaikin Marat, Bracho Jorge, Luo Cheng Hua, Weiss Eric G, Sands Dana R, Cera Susan, Nogueras Juan J, Wexner Steven D
Department of Colorectal Surgery, Cleveland Clinic Florida, 2950, Cleveland clinic Blvd., Weston, FL 33332, USA.
Int J Colorectal Dis. 2007 Nov;22(11):1389-93. doi: 10.1007/s00384-007-0344-5. Epub 2007 Aug 14.
Solitary rectal ulcer syndrome (SRUS) is a rare disorder often misdiagnosed as a malignant ulcer. Histopathological features of SRUS are characteristic and pathognomonic; nevertheless, the endoscopic and clinical presentations may be confusing. The aim of the present study was to assess the clinical findings, surgical treatment, and outcomes in patients who suffer from SRUS.
A retrospective chart review was undertaken, from January 1989 to May 2005 for all patients who were diagnosed with SRUS. Data recorded included: patient's age, gender, clinical presentation, past surgical history, diagnostic and preoperative workup, operative procedure, complications, and outcomes.
During the study period, 23 patients were diagnosed with SRUS. Seven patients received only medical treatment, and in three patients, the ulcer healed after medical treatment. Sixteen patients underwent surgical treatment. In four patients, the symptoms persisted after surgery. Two patients presented with postoperative rectal bleeding requiring surgical intervention. Three patients developed late postoperative sexual dysfunction. One patient continued suffering from rectal pain after a colostomy was constructed. Median follow-up was 14 (range 2-84) months.
The results of this study show clearly that every patient with SRUS must be assessed individually. Initial treatment should include conservative measures. In patients with refractory symptoms, surgical treatment should be considered. Results of anterior resection and protocolectomy are satisfactory for solitary rectal ulcer.
孤立性直肠溃疡综合征(SRUS)是一种罕见疾病,常被误诊为恶性溃疡。SRUS的组织病理学特征具有特异性和诊断性;然而,其内镜表现和临床表现可能令人困惑。本研究的目的是评估SRUS患者的临床发现、手术治疗及预后。
对1989年1月至2005年5月期间所有诊断为SRUS的患者进行回顾性病历审查。记录的数据包括:患者年龄、性别、临床表现、既往手术史、诊断及术前检查、手术操作、并发症及预后。
在研究期间,23例患者被诊断为SRUS。7例患者仅接受药物治疗,其中3例患者经药物治疗后溃疡愈合。16例患者接受了手术治疗。4例患者术后症状持续存在。2例患者术后出现直肠出血,需要手术干预。3例患者术后出现晚期性功能障碍。1例患者在造口术后仍持续存在直肠疼痛。中位随访时间为14(2 - 84)个月。
本研究结果清楚地表明,每位SRUS患者都必须进行个体化评估。初始治疗应包括保守措施。对于症状难治的患者,应考虑手术治疗。前切除术和全结肠切除术治疗孤立性直肠溃疡的效果令人满意。