一份问卷模块EORTC QLQ - OG25的临床和心理测量学验证，用于评估食管癌、食管胃交界癌和胃癌患者与健康相关的生活质量。
Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago-gastric junction and the stomach.
作者信息
Lagergren Pernilla, Fayers Peter, Conroy Thierry, Stein Hubert J, Sezer Orhan, Hardwick Richard, Hammerlid Eva, Bottomley Andrew, Van Cutsem Eric, Blazeby Jane M
机构信息
Department of Social Medicine at South Bristol, University of Bristol, Bristol, United Kingdom.
出版信息
Eur J Cancer. 2007 Sep;43(14):2066-73. doi: 10.1016/j.ejca.2007.07.005. Epub 2007 Aug 15.
AIM
To combine and test the EORTC questionnaires for assessing quality of life (HRQL) for oesophageal (QLQ-OES18) and stomach cancer (QLQ-STO22), into a single questionnaire for tumours of the oesophagus, oesophago-gastric junction or stomach.
METHODS
The QLQ-OES18, QLQ-STO22 and seven modified items were administered to 300 patients with oesophageal (n=148), junctional (n=66), or gastric cancer (n=86). Semi-structured interviews assessed item and scale preference and multi-trait scaling analyses confirmed the scale structure of the new module (QLQ-OG25). This was further tested for validity.
RESULTS
The QLQ-OG25 has six scales, dysphagia, eating restrictions, reflux, odynophagia, pain and anxiety. Scales have good reliability (alpha range 0.67-0.87) and they distinguish between tumour sites and disease stage. Scales do not correlate highly with scores from the core questionnaire, thus indicating that the module was addressing separate HRQL aspects.
CONCLUSION
The QLQ-OG25 is recommended to supplement the EORTC QLQ-C30 when assessing HRQL in patients with oesophageal, junctional or gastric cancer.
目的
将欧洲癌症研究与治疗组织（EORTC）用于评估食管癌（QLQ - OES18）和胃癌（QLQ - STO22）患者生活质量（HRQL）的问卷合并并测试，形成一个用于食管、食管胃交界或胃癌患者的单一问卷。
方法
将QLQ - OES18、QLQ - STO22及七个修改项应用于300例食管癌（n = 148）、交界性癌（n = 66）或胃癌（n = 86）患者。半结构化访谈评估项目和量表偏好，多特质量表分析确认了新模块（QLQ - OG25）的量表结构，并进一步对其有效性进行了测试。
结果
QLQ - OG25有六个量表，分别为吞咽困难、饮食限制、反流、吞咽痛、疼痛和焦虑。这些量表具有良好的信度（α系数范围为0.67 - 0.87），且能区分肿瘤部位和疾病分期。这些量表与核心问卷得分的相关性不高，表明该模块涉及不同的HRQL方面。
结论
建议在评估食管癌、交界性癌或胃癌患者的HRQL时，使用QLQ - OG25补充EORTC QLQ - C30。
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