Grupo de Lactamas y Heterociclos Bioactivos, Departamento de Química Orgánica I, Unidad Asociada al CSIC, Facultad de Química, Universidad Complutense de Madrid, 28040-Madrid, Spain.
Molecules. 2011 Sep 13;16(9):7815-43. doi: 10.3390/molecules16097815.
The last decade has witnessed dramatic growth in the number of reactions catalyzed by gold complexes because of their powerful soft Lewis acid nature. In particular, the gold-catalyzed activation of propargylic compounds has progressively emerged in recent years. Some of these gold-catalyzed reactions in alkynes have been optimized and show significant utility in organic synthesis. Thus, apart from significant methodology work, in the meantime gold-catalyzed cyclizations in alkynol derivatives have become an efficient tool in total synthesis. However, there is a lack of specific review articles covering the joined importance of both gold salts and alkynol-based compounds for the synthesis of natural products and derivatives. The aim of this Review is to survey the chemistry of alkynol derivatives under gold-catalyzed cyclization conditions and its utility in total synthesis, concentrating on the advances that have been made in the last decade, and in particular in the last quinquennium.
过去十年，由于金配合物具有强大的软路易斯酸性质，其催化的反应数量显著增加。特别是，近年来金催化的炔丙基化合物的活化作用逐渐显现。其中一些炔烃中的金催化反应已经得到优化，并在有机合成中显示出显著的实用性。因此，除了重要的方法学工作外，同时金催化的炔醇衍生物环化反应已成为全合成中的有效工具。然而，缺乏涵盖金盐和炔醇类化合物在天然产物和衍生物合成中同等重要性的综述文章。本文综述的目的是调查金催化环化条件下炔醇衍生物的化学性质及其在全合成中的应用，重点介绍过去十年，特别是过去五年所取得的进展。
