天然来源的内生真菌青霉属中 5/5/5 螺环倍半萜内酯化合物紫穗槐苷 A。

Purpurolide A, 5/5/5 Spirocyclic Sesquiterpene Lactone in Nature from the Endophytic Fungus Penicillium purpurogenum.

机构信息

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , People's Republic of China.

Institute of Interdisciplinary Medicine , Shanghai University of Traditional Chinese Medicine , Shanghai 201203 , People's Republic of China.

出版信息

Org Lett. 2018 Nov 16;20(22):7341-7344. doi: 10.1021/acs.orglett.8b03323. Epub 2018 Nov 5.

DOI:10.1021/acs.orglett.8b03323

PMID:30394758

Abstract

Purpurolide A (1), an unprecedent sesquiterpene lactone with a rarely encountered 5/5/5 spirocyclic skeleton, along with two new 6/4/5/5 tetracyclic sesquiterpene lactones (2 and 3), were isolated from the cultures of the endophytic fungus Penicillium purpurogenum IMM003. The structures and absolute configurations of 1-3 were established by spectroscopic analysis, single-crystal X-ray diffraction, and calculations of the C NMR and ECD data. Compounds 1-3 showed significant inhibitory activity against pancreatic lipase.

摘要

紫堇醇灵 A（1）是一种具有前所未有的 5/5/5 螺环骨架的倍半萜内酯，以及两个新的 6/4/5/5 四环倍半萜内酯（2 和 3），从内生真菌青霉属 purpurogenum IMM003 的培养物中分离得到。通过光谱分析、单晶 X 射线衍射和 C NMR 和 ECD 数据的计算，确定了 1-3 的结构和绝对构型。化合物 1-3 对胰脂肪酶表现出显著的抑制活性。