Muneta S, Murakami E, Sumimoto T, Iwata T, Hiwada K, Sato Y, Imamura Y
Second Department of Internal Medicine, Ehime University School of Medicine, Japan.
J Hum Hypertens. 1991 Oct;5(5):393-8.
To investigate the circadian profiles of BP and heart rate in elderly patients with isolated systolic hypertension (ISH), the variability of BP and heart rate during day time (daytime) and the amplitudes of nocturnal fall were evaluated in ISH (n = 19) comparing with those of essential hypertensive patients (EHT, n = 18) and normotensive subjects (NT, n = 16) in the same age range. ISH showed a significantly wider BP variability during the day time and a greater amplitude of nocturnal fall compared with EHT and NT. However, the heart rate variability during the daytime and the amplitude of nocturnal fall were similar among the three groups. ISH showed a stronger correlation between BP and heart rate during 24 hours compared with EHT and NT. Approximately 80% of ISH showed a significant positive correlation between BP and heart rate. These results suggest that the BP of ISH patients is susceptible to fluctuations in autonomic nerve activity.
为研究老年单纯收缩期高血压（ISH）患者血压和心率的昼夜变化情况，对ISH患者（n = 19）日间（白天）血压和心率的变异性以及夜间下降幅度进行了评估，并与相同年龄范围的原发性高血压患者（EHT，n = 18）和血压正常者（NT，n = 16）进行比较。与EHT和NT相比，ISH患者白天血压变异性显著更大，夜间下降幅度更大。然而，三组之间白天心率变异性和夜间下降幅度相似。与EHT和NT相比，ISH患者24小时内血压与心率之间的相关性更强。约80%的ISH患者血压与心率呈显著正相关。这些结果表明，ISH患者的血压易受自主神经活动波动的影响。
