Sumimoto T, Murakami E, Hiwada K
Second Department of Internal Medicine, Ehime University School of Medicine, Japan.
J Hum Hypertens. 1991 Oct;5(5):411-5.
Plasma immunoreactive atrial natriuretic factor (ANF) and urinary sodium excretion were measured in elderly patients with isolated systolic hypertension (ISH) (n = 11), age-matched essential hypertensive patients (EHT; n = 16) and normotensive subjects (NT; n = 9) before and during a 60 min infusion of hypertonic saline (120 mEq of Na+). An exaggerated natriuresis during the sodium load was observed only in ISH. Baseline plasma ANF levels in ISH were significantly lower (P less than 0.05) than those of EHT and NT. There was no significant change in plasma ANF in EHT and NT subjects after the saline load. In contrast, there was a significant increase in plasma ANF (P less than 0.05) after the saline load in ISH. The change in urinary sodium excretion was significantly correlated with the change in plasma ANF (r = 0.75, P less than 0.01) in ISH. We conclude that an exaggerated natriuresis during a hypertonic saline infusion may be linked to an increase in plasma ANF in elderly ISH patients.
在老年单纯收缩期高血压（ISH）患者（n = 11）、年龄匹配的原发性高血压患者（EHT；n = 16）和血压正常者（NT；n = 9）中，于静脉输注高渗盐水（120 mEq的Na+）60分钟之前及期间，测定血浆免疫反应性心房利钠因子（ANF）和尿钠排泄量。仅在ISH患者中观察到钠负荷期间出现过度利尿。ISH患者的基线血浆ANF水平显著低于EHT和NT患者（P < 0.05）。盐水负荷后，EHT和NT受试者的血浆ANF无显著变化。相比之下，ISH患者在盐水负荷后血浆ANF显著升高（P < 0.05）。ISH患者尿钠排泄量的变化与血浆ANF的变化显著相关（r = 0.75，P < 0.01）。我们得出结论，高渗盐水输注期间的过度利尿可能与老年ISH患者血浆ANF的增加有关。
