Erythema multiforme in two horses.

Erythema multiforme is reported for the first time in 2 South African horses. Both horses displayed a sudden, fulminant outbreak of raised, non-alopecic and non-pruritic plaques over the dorsolateral aspects of the neck and trunk. In both cases the distribution of the lesions was bilaterally symmetrical. Histopathological findings included hydropic degeneration of basal epidermal cells, eosinophilic necrosis of individual or groups of keratinocytes, intra-epidermal and sub-epidermal cleft formation and mixed, dermal, perivascular infiltrates. An initiating cause could not be identified in either case. Both horses underwent gradual spontaneous remission within 3 months.