Büch U, Altmayer P, Isenberg J C, Büch H P
Department of Pharmacology and Toxicology, University of the Saarland, Homburg, Germany.
Methods Find Exp Clin Pharmacol. 1991 Dec;13(10):687-91.
Thiopental distribution was studied in rats (30 mg/kg i.v.) anesthetized simultaneously with 1.25 "rat"-MAC isoflurane. The thiopental concentration in serum and several tissues was determined UV-photometrically at 305 nm after extraction and TLC. In the serum of rats anesthetized with isoflurane the thiopental concentration was significantly increased to +39----+74% in comparison to controls during 30 min following the barbiturate injection. Also in liver, brain, heart, kidney, lung and spleen of rats anesthetized with isoflurane the thiopental concentration was significantly increased at 3 and 10 min; at 30 min the difference vs. control had vanished in brain, heart, lung and spleen. Obviously, thiopental was transiently "trapped" during the early distribution phase to a considerable amount in these vessel-rich tissues when anesthesia with isoflurane was simultaneously performed; this pharmacokinetic interaction might be explained at least to some extent hemodynamically; in many tissues regional blood flow is reduced during anesthesia with isoflurane; thereby the "washout" of thiopental from the tissues and the redistribution are delayed.
在与1.25倍“大鼠”最低肺泡有效浓度（MAC）的异氟烷同时麻醉的大鼠（静脉注射30mg/kg）中研究了硫喷妥钠的分布。在提取和薄层色谱法（TLC）后，于305nm处通过紫外光度法测定血清和几种组织中的硫喷妥钠浓度。与对照组相比，在用异氟烷麻醉的大鼠血清中，在注射巴比妥酸盐后的30分钟内，硫喷妥钠浓度显著升高至+39%----+74%。在用异氟烷麻醉的大鼠的肝脏、大脑、心脏、肾脏、肺和脾脏中，在3分钟和10分钟时硫喷妥钠浓度也显著升高；在30分钟时，大脑、心脏、肺和脾脏与对照组的差异消失。显然，在同时使用异氟烷麻醉时，硫喷妥钠在早期分布阶段会在这些血管丰富的组织中大量短暂“滞留”；这种药代动力学相互作用至少在一定程度上可以从血流动力学角度来解释；在许多组织中，异氟烷麻醉期间局部血流会减少；从而硫喷妥钠从组织中的“清除”和再分布会延迟。
