Vairaktaris Eleftherios, Goutzanis Lambros, Nkenke Emeka, Spyridonidou Sofia, Vassiliou Stavros, Derka Spyridoula, Vylliotis Antonis, Yapijakis Christos, Lazaris Andreas, Strantzias Pashalis, Kalimeras Eleftherios, Patsouris Efstratios
Department of Oral and Maxillofacial Surgery, University of Athens Medical School, Athens, Greece.
In Vivo. 2007 Jul-Aug;21(4):623-8.
Increased expression of fibroblast growth factors and their receptors (FGFRs) has recently been described in oral squamous cell carcinoma. In addition, we have previously described a molecular basis for an association between oral cancer and diabetes. The expression of FGFR-2 and FGFR-3 investigated in an experimental model of chemically induced carcinogenesis in normal and diabetic (type I) rats.
Tissue sections ranging from normal mucosa to moderately-differentiated oral squamous cell carcinoma were studied using monoclonal antibodies against FGFR-2 and FGFR-3 proteins.
A similar pattern of elevated FGFR-2 and FGFR-3 expression was observed in the initial stages of oncogenesis for both diabetic and non-diabetic animals. In the last stages of oral oncogenesis, the expression of both proteins remained relatively stable.
It seems that diabetes does not affect the FGFR-2 and FGFR-3 pattern of expression throughout the various stages of oral oncogenesis.
最近在口腔鳞状细胞癌中发现成纤维细胞生长因子及其受体（FGFRs）的表达增加。此外，我们之前描述过口腔癌与糖尿病之间关联的分子基础。在正常和糖尿病（I型）大鼠化学诱导致癌的实验模型中研究了FGFR - 2和FGFR - 3的表达。
使用针对FGFR - 2和FGFR - 3蛋白的单克隆抗体研究从正常黏膜到中度分化口腔鳞状细胞癌的组织切片。
在糖尿病和非糖尿病动物肿瘤发生的初始阶段，观察到FGFR - 2和FGFR - 3表达升高的相似模式。在口腔肿瘤发生的最后阶段，两种蛋白的表达保持相对稳定。
糖尿病似乎在口腔肿瘤发生的各个阶段均不影响FGFR - 2和FGFR - 3的表达模式。
