Matsuno Yosuke, Okamoto Mariko, Hirasawa Yusuke, Kawahara Nobuo, Goda Yukihiro, Shiro Motoo, Morita Hiroshi
Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo, Japan.
J Nat Prod. 2007 Sep;70(9):1516-8. doi: 10.1021/np070226g. Epub 2007 Aug 21.
The new Daphniphyllum alkaloids, pordamacrines A (1) and B (2), have been isolated from the leaves of Daphniphyllum macropodum, and their structures were elucidated on the basis of interpretation of spectroscopic data and by the single-crystal X-ray diffraction analysis of 2. Pordamacrines A (1) and B (2) exhibited moderate vasorelaxant effects on the rat aorta.
从大葉虎皮楠（Daphniphyllum macropodum）的叶子中分离出了新的虎皮楠生物碱——坡达马环胺A（1）和坡达马环胺B（2），并通过光谱数据分析和对2的单晶X射线衍射分析确定了它们的结构。坡达马环胺A（1）和坡达马环胺B（2）对大鼠主动脉表现出中等程度的血管舒张作用。
